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Example sentences for: shbg
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The intraclass correlation coefficient ICC s for absolute agreement between the two analysis batches ranged from ICC (2,1) = 0.47 to ICC (2,1) = 0.96 (for E 1 and SHBG respectively, Table 4).
The percent of true variance accounted for by a single measurement ranged from 29% to 92% for LH and SHBG respectively.
This study confirms previous findings that SHBG may be reliably measured in premenopausal women using a single occasion.
, [ 10 12 13 14 15 ] ]. It is thought to regulate spermatogenesis and sperm maturation by maintaining high androgen levels in the testis and epididymis [ 16 17 ] and has been proposed as a biochemical marker for Sertoli cell function and formation of blood-testis barrier [ 12 18 ] . More recently, cell surface receptors for ABP and its liver-derived homolog sex hormone-binding globulin (SHBG) were identified in several androgen target tissues, suggesting that these extracellular steroid-binding proteins may have a much broader, hormone-like function [ 19 20 21 ] .
Obesity is also associated with significant hormonal changes such as decreased serum estradiol and sex hormone binding globulin (SHBG) levels, increased peripheral fat conversion of estrogens to progesterone and increased serum testosterone levels that may be associated with an increased risk of breast cancer [ 17 ] . Estrogens are necessary for normal breast development, and they induce and promote mammary tumor growth in animal studies [ 18 ] . In addition, the close association between increased risk of breast cancer and certain reproductive factors such as early menarche and late menopause [ 19 ] , as well as the fall off in the rate of increase in the incidence of disease at menopause [ 20 ] and the lowered risk of breast cancer in oophorectomized women and those taking antiestrogens [ 21 22 ] , all support the role of estrogen in breast carcinogenesis.
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