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Example sentences for: shbg
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Second, obtaining blood and urine samples on day 5 following ovulation was most appropriate for the measurement of progesterone and near-optimal for SHBG, but may not have been the best day to obtain estimates of the other analytes [ 25 ] . Third, though our data were drawn from an intervention study in which no results approached significance, a more clearly homogeneous sample would have been preferable.
Free E 2 (non-SHBG or albumin-bound-E 2 ) was determined by calculation using a computerized algorithm described previously).)
E 1 S, progesterone and SHBG were measured by direct RIAs using kits obtained from Diagnostic Systems Laboratories, Webster, Texas.
Obesity is also associated with significant hormonal changes such as decreased serum estradiol and sex hormone binding globulin (SHBG) levels, increased peripheral fat conversion of estrogens to progesterone and increased serum testosterone levels that may be associated with an increased risk of breast cancer [ 17 ] . Estrogens are necessary for normal breast development, and they induce and promote mammary tumor growth in animal studies [ 18 ] . In addition, the close association between increased risk of breast cancer and certain reproductive factors such as early menarche and late menopause [ 19 ] , as well as the fall off in the rate of increase in the incidence of disease at menopause [ 20 ] and the lowered risk of breast cancer in oophorectomized women and those taking antiestrogens [ 21 22 ] , all support the role of estrogen in breast carcinogenesis.
, [ 10 12 13 14 15 ] ]. It is thought to regulate spermatogenesis and sperm maturation by maintaining high androgen levels in the testis and epididymis [ 16 17 ] and has been proposed as a biochemical marker for Sertoli cell function and formation of blood-testis barrier [ 12 18 ] . More recently, cell surface receptors for ABP and its liver-derived homolog sex hormone-binding globulin (SHBG) were identified in several androgen target tissues, suggesting that these extracellular steroid-binding proteins may have a much broader, hormone-like function [ 19 20 21 ] .
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