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Example sentences for: sh
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2B): Coelomata continued to be significantly supported (≥ 98% bootstrap support, posterior probability = 1.0) and the alternative hypotheses were both rejected using the SH test ( P < 0.001), although the relationships among the basal phyla (Nematoda and Platyhelminthes) could not be resolved.
GST fusions encoding the Rlk amino-terminal and SH3 domains or the amino-terminus alone (containing the cysteine string and proline-rich region) bound biotinylated GST fusions of the SH3 domains of Fyn, Hck, and Lyn, but not those of Src or Lck, despite the ability of these constructs to bind other proline rich sequences (Fig.
The DLG5 gene encodes for a protein that is a member of the MAGUK (Membrane Associated Guan late Kinase homologs) family of proteins located in the plasma membrane [ 2 ] . MAGUK is a new family of proteins that act as a molecular scaffold for intracellular signaling pathways [ 11 ] . The MAGUK family of proteins is characterized by domains that interact with other proteins to create an assembly of large multi-protein complexes [ 10 ] . The PDZ (PSD-95, DLG and ZO-1) domains are the best characterized for their binding to the C-terminal region of channels and transmembrane proteins [ 11 ] . Usually each protein has 1-3 copies of such domains [ 8 12 13 ] . The SH3 domain (Src homology 3) are present in proteins that couple transmembrane receptors to signaling molecules [ 14 ] . The presence of this domain in MAGUKs increases their possibilities of interacting with signaling pathways.
Thus, these proteins contain fusions of the NlpC/P60 peptidase domain with the SH3, choline-binding, LysM, lysozyme and NAM amidase domains (Figure 4), and this implicates them in different processes in cell-wall dynamics.
Thus while both sets of motifs in the Cas SD have been thought to interact with the v-crk SH2 domain, we demonstrated that this domain only interacts with the YDXP motifs.
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