Words similar to sh

Example sentences for: sh

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To address this issue, we used the following mutant versions of Boi1: the "S" mutant, which contains a Lys residue in place of a Trp residue at a highly conserved position in the SH3 domain; the "P" mutant, in which seven of the nine Pro residues in the Pro-rich region are replaced with Ala residues (a version of Boi1 that does not bind Bem1); and the "SP" mutant, which contains both the "S" and "P" changes [ 1 ] .
Upon BCR stimulation, Btk is thought to be recruited to PLCγ2 via the adapter protein BLNK, as BLNK can associate with the SH2 domains of both PLCγ2 [ 31, 32] and Btk [ 33].
A few ancient and widespread β-rich folds such as the SH3-like barrel and the OB fold appear to have colonized multiple functional niches early in evolution, although their earliest versions may have had roles related to RNA metabolism [ 9, 11, 12, 13].
These data indicate that the v-crk SH2 domain interacts with the C-terminal YDXP motifs, and as suggested by Birge et al, v-crk may be able to protect them from dephosphorylation and/or induces their phosphorylation [ 12 ] . They also suggest that the YQXP motifs may be involved in binding to other intracellular signaling molecules.
The SH2 domain-containing inositol phosphatase (SHIP) downregulates Btk by dephosphorylating PIP3 [ 4, 5, 6].