Words similar to sh
Example sentences for: sh
How can you use “sh” in a sentence? Here are some example sentences to help you improve your vocabulary:
Meaning to say cheated, she had articulated sh in place of ch and the i of sit in place of the ea .
We then used the 5' and 3' fusions of the Cas SD to determine which motif, YQXP or YDXP, interacts with the v-crk SH2 domain.
SH participated in design and coordination of the study and finalized the manuscript, which has been read and approved by all authors.
Cas is a protein which migrates with an apparent mass of approximately 130 kDa, with a N-terminal SH3 domain, a central substrate domain (SD) with up to 15 tyrosines which can be phosphorylated, a C-terminal region with a proline-rich region, and two tyrosine phosphorylation sites capable of binding Src kinases (Src binding domain (SBD)) [ 6 18 ] . The latter SBD domain regulates the ability of Src to activate the serum response element, as well as in the phosphorylation of the SD of Cas by Src [ 18 19 20 ] . The substrate domain controls adhesion and migration and the majority of the tyrosines within this domain are of the sequence YQXP (5) or YDXP (10), which when phosphorylated, bind to the adaptors c-crk, nck and AND-34 [ 16 21 22 23 ] . The importance of these molecules in Cas function is unclear, however c-crk seems to be critical in the regulation of adhesion and migration mediated by Cas.
Figure 4ademonstrates that while the chimera was not stably tyrosine phosphorylated when expressed alone, expression of the Src KM/Cas(SD) chimera along with either WT or an SH3 domain mutant of v-crk resulted in its stable tyrosine phosphorylation and co-immunoprecipitation with v-crk (Fig.
Loading...