Words similar to sh

Example sentences for: sh

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Initially, we expressed the Src KM/Cas(SD) (entire Cas SD) in Cos-7 cells alone, or along with wild type (WT) v-crk, or v-crk SH2 or SH3 mutants and assayed for tyrosine phosphorylation and association by co-immunoprecipitation (Fig.
[ 18 ] . This constitutively activated Stat3 (a mutant produced by substitution of the cysteine residues within the COOH-terminal loop of the SH2 domain of Stat3) induces cellular transformation and tumor formation in nude mice [ 18 ] . The plasmids to express other coactivators (SRC-1, CBP/p300, TIF2 and PCAF) have been described elsewhere [ 29 30 ] .
Each contains an SH3 domain; a SAM (sterile alpha motif) domain; a proline-rich region, which mediates binding to the second SH3 domain of Bem1; and a PH domain [ 1 2 3 ] . Figure 1shows the relative positions of these sequence features in Boi1.
Although physical binding of full length Btk to Src family kinases in vivo has not been reported, in vitro interactions have been demonstrated between proline-rich motifs in the amino-terminal sequence of Btk and the Src homology (SH) 3 domains of Src family kinases [ 25, 26].
The major autophosphorylation site in Btk maps to Y223 within the SH3 domain [ 24]; an analogous tyrosine is conserved in Rlk (Y91).