Words similar to serines
Example sentences for: serines
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In addition, DNA damage increases the phosphorylation of serines 33 and 37 of p53 through an ATM-independent mechanism [ 15, 16, 17, 18].
The opossum alpha-2C adrenergic receptor has a very similar acidic serine motif (EESSTSE) in the third intracellular loop (Figure 1; [ 21 ] ), whereas the human alpha-2C receptor has a DESSAAAE sequence in the same region (Figure 2; [ 22 ] ). Thus, we postulated that the lack of down-regulation in the human alpha-2C was related to having only two rather than four serines in the motif, and furthermore that the ability of the opossum alpha-2C to undergo down-regulation was dependent on having all four serine/threonine residues in the EESSTSE motif.
To test this hypothesis, we mutated the opossum alpha-2C serines and threonine residues to alanines and valine, respectively, and tested whether the expressed receptors would down-regulate.
[Reviewed in [ 26 ] ]. In addition, each ZAS protein contains a sequence similar to the serine stripe present in basonuclin, in which eight serines are located on one side of a putative α-helix [ 13 27 ] .
Human wild type p53 or p53 bearing mutations in serines 33 or 37 were inserted into the BamH1 site of the pcDNA3.