Words similar to serine
Example sentences for: serine
How can you use “serine” in a sentence? Here are some example sentences to help you improve your vocabulary:
TNFα rapidly and potently activates Rel A and p50 subunits of NF-κB through a kinase-mediated phosphorylation cascade involving a high molecular mass signaling complex called the IKK complex [ 56 ] . TNFα activation of the multiprotein IKK complex results in the serine phorsphorylation of I-κB and the subsequent activation of NF-κB [ 57 ] .
The possible functional significance of this paralog as serine deaminase has been discussed elsewhere [ 30].
In L1, the residue at position 224 is a serine [ 35 ] , and the substrate-binding model for L1 predicts that this serine residue interacts with the carboxylate on substrate via a water molecule [ 37 ] . To test the proposed role of Ser224 in L1, serine was changed to an alanine (S224A), aspartic acid (S224D), and lysine (S224K), and these mutants were characterized using metal analyses, CD spectroscopy, steady-state kinetics, and pre-steady state kinetic studies.
The L-serine + indole → H 2 O + L-tryptophan reaction might function alone for tryptophan biosynthesis in cells that acquire indole from the environment.
One of the major cellular serine/threonine protein phosphatases is protein phosphatase type 1 (PP1) [ 1 ] . An abundant enzyme expressed in all cells, complex regulation of PP1 is thought to be essential for proper temporal and spatial regulation of PP1 catalytic activity towards individual substrates [ 2 ] . Three different isotypes of the catalytic subunit, designated PP1α, PP1δ, and PP1γ1, are expressed in many different cell types [ 3 ] . Studies employing many eukaryotic systems all point to a crucial role for PP1 activity in controlling cell cycle progression, and an absolute requirement of this activity for mitotic exit [ 4 5 6 7 ] . There is also evidence to suggest that phosphorylation of PP1 and its associated proteins by the cyclin-dependent kinases may regulate PP1 activity in a cell cycle stage-dependent manner [ 8 9 10 ] . Hence, current efforts are directed towards identification of cell cycle-dependent substrates for PP1, and how regulation of PP1 activity towards these substrates controls the cell division cycle.
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