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Example sentences for: sequestered

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First, downregulation of cyclin D1 leads to release of p27 Kip1sequestered by the cyclin D1/CDK4 complex.
SMAD4 (DPC4) is essential for this TGFβ 1 signaling and transcriptional activation process [ 16 ] . In epithelial cells, TGFβ 1 decreases c-myc, cdc2 and cyclin D1 expression, and it increases the expression of c-jun and c-fos [ 17 18 19 20 21 22 23 ] . Activation of the TGFβ 1 signal pathway in epithelial cells leads to an increased expression of the cell cycle inhibitors p21 WAF1and p15 Ink4band to a release of formerly sequestered p27 KIP [ 24 25 26 ] . It is assumed that the cooperative action of these cell cycle inhibitors results in the growth arrest mentioned above, although p15 Ink4bdoes not seem to be necessary in this regard.
Positive results on the rapid test, which can not be verified microscopically have been suggested to be due to circulating P. falciparum HRP-2 antigen following treatment [ 20 ] or from sequestered parasites [ 21 ] .
The finding that sequestered parasite biomass is associated with disease severity fits with current thinking that sequestration of erythrocytes containing the mature forms of the parasite is the central pathological process in falciparum malaria.
However, sequestered