Words similar to secy

Example sentences for: secy

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The signal sequence is crucial for efficient translocation; mutations in the signal sequence significantly reduce export of the preprotein and complete deletions of the signal sequence eliminate essentially all export [ 5 6 7 8 ] . Selection for extragenic suppressors of such export defective preproteins led to the identification of the prl alleles of secY ( prlA ), secE ( prlG ), secA ( prlD ), and more recently secG ( prlH ) [ 6 9 10 11 ] . Early hypotheses predicted that the Prl suppressors function by expanded or altered interactions with signal sequences, facilitating recognition of mutant as well as wild type signal sequences [ 6 ] .
According to the proofreading model, in a wild type strain, SecE and SecY would reject the unfolded protein due to lack of a signal sequence.
Plasmids pKL106 and pKL107 encoding LA57-N 102LT-FLAG or N 102LT-FLAG, respectively, were transformed into strains IM104 (wild type secY ) or IM105 ( prlA4 ). These strains contained deletion mutations in the lon and degP genes to limit proteolysis in both the cytoplasmic and periplasmic spaces.
The PrlA (SecY) and PrlG (SecE) suppressors are compromised in their ability to proofread, allowing export of proteins with mutations, or even complete deletions, of the signal sequence.
In the secY wild type strain, proofreading by SecE/Y would block export of LA57-N 102LT, while in the prlA4 strain, the PrlA4 suppressor would allow export of a portion of LA57-N 102LTto the periplasm.