Words similar to seca

Example sentences for: seca

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Both SecB and the preprotein provide binding sites for SecA, a peripheral membrane ATPase.
SecA targets the preprotein to the membranous translocase complex composed of SecY, SecE, SecG, SecD, SecF, and YajC.
Formation of the complete translocase complex promotes an ATP binding and hydrolysis cycle by SecA that results in segmental translocation of the secretory protein across the membrane [ 1 2 3 4 ] .
The signal sequence is crucial for efficient translocation; mutations in the signal sequence significantly reduce export of the preprotein and complete deletions of the signal sequence eliminate essentially all export [ 5 6 7 8 ] . Selection for extragenic suppressors of such export defective preproteins led to the identification of the prl alleles of secY ( prlA ), secE ( prlG ), secA ( prlD ), and more recently secG ( prlH ) [ 6 9 10 11 ] . Early hypotheses predicted that the Prl suppressors function by expanded or altered interactions with signal sequences, facilitating recognition of mutant as well as wild type signal sequences [ 6 ] .
SecB binds portions of the mature secretory protein [ 14 15 16 17 18 ] , and SecA would bind to the SecB-precursor complex by virtue of its ability to bind SecB [ 19 20 ] as well as the preprotein [ 21 22 23 ] . Thus, SecA-mediated targeting of the preprotein to translocase would occur.