Words similar to seca

Example sentences for: seca

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Formation of the complete translocase complex promotes an ATP binding and hydrolysis cycle by SecA that results in segmental translocation of the secretory protein across the membrane [ 1 2 3 4 ] .
The signal sequence is crucial for efficient translocation; mutations in the signal sequence significantly reduce export of the preprotein and complete deletions of the signal sequence eliminate essentially all export [ 5 6 7 8 ] . Selection for extragenic suppressors of such export defective preproteins led to the identification of the prl alleles of secY ( prlA ), secE ( prlG ), secA ( prlD ), and more recently secG ( prlH ) [ 6 9 10 11 ] . Early hypotheses predicted that the Prl suppressors function by expanded or altered interactions with signal sequences, facilitating recognition of mutant as well as wild type signal sequences [ 6 ] .
Both SecB and the preprotein provide binding sites for SecA, a peripheral membrane ATPase.
SecA targets the preprotein to the membranous translocase complex composed of SecY, SecE, SecG, SecD, SecF, and YajC.
SecB binds portions of the mature secretory protein [ 14 15 16 17 18 ] , and SecA would bind to the SecB-precursor complex by virtue of its ability to bind SecB [ 19 20 ] as well as the preprotein [ 21 22 23 ] . Thus, SecA-mediated targeting of the preprotein to translocase would occur.