Words similar to scale-independent
Example sentences for: scale-independent
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USM representations of discrete sequences in genomics and proteomics offer the possibility of scale-independent representations of sequence information surrounding points of comparison in those sequences.
The application of USM as a tool for measuring scale-independent discrete sequence similarity and its particular application to genomics and proteomics exploits a distance metric providing an estimate of the length of similar regions surrounding a pair of symbols.
For over a decade the idea of representing biological sequences in a continuous coordinate space has maintained its appeal but not been fully realized [ 1 2 3 ] . The basic idea is that sequences of symbols, such as nucleotides in genomes, aminoacids in proteomes, repeated sequences in MLST [Multi Locus Sequence Typing, 4], words in languages or letters in words, would define trajectories in this continuous space conserving the statistical properties of the original sequences [ 3 5 6 7 8 9 ] . Accordingly, the coordinate position of each unit would uniquely encode for both its identity and its context, i.e. the identity of its neighbors [ 10 ] . Ideally, the position should be scale-independent, such that the extraction of the encompassing sequence can be performed with any resolution, leading to an oligomer of arbitrary length.
It could then be argued that, given the discrete nature of biological sequences, new scale-independent numerical representations, such as USM, are all but the first step in the identification of more accurate Boolean equivalents of fundamental relevance.
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