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Example sentences for: sbhms

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In addition to the SBHMs that are conserved among all bacterial lineages, a cassette of up to four SBHMs are present N-terminal of the DPBB domain in the β' subunit of Thermus , Deinococcus and Thermotoga (Fig.
None of these additional SBHMs were detectable in the archaeal or eukaryotic DDRPs, either in sequence searches or in direct comparisons of the crystal structures.
In addition to the specific structural relationship between some of the SBHMs of the DDRPs and those present in these bacterial proteins, they also show detectable sequence similarity.
Two of these SBHMs (regions 163-195 and 369-419 in 1iw7 chain D) are involved in the interaction with the σ 70 subunit, which is critical for transcription initiation in bacteria [ 23 ] . Thus, it appears likely that, originally, the SBHM domain of the β subunit participated in generic protein-protein interactions that allowed the ancestral DDRP to recruit accessory subunits.
These observations reveal an evolutionary relationship between the SBHM domain of DDRP and the SBHMs found in other, functionally distinct proteins.