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Example sentences for: sbhms
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In addition to the specific structural relationship between some of the SBHMs of the DDRPs and those present in these bacterial proteins, they also show detectable sequence similarity.
None of these additional SBHMs were detectable in the archaeal or eukaryotic DDRPs, either in sequence searches or in direct comparisons of the crystal structures.
Two of these SBHMs (regions 163-195 and 369-419 in 1iw7 chain D) are involved in the interaction with the σ 70 subunit, which is critical for transcription initiation in bacteria [ 23 ] . Thus, it appears likely that, originally, the SBHM domain of the β subunit participated in generic protein-protein interactions that allowed the ancestral DDRP to recruit accessory subunits.
Subsequently, in the bacterial lineage, proliferation of SBHMs provided for several other, specific interactions involved in initiation and elongation.
For example, a PSI-BLAST search initiated with the SBHM from NlpD retrieved the derived SBHMs of the bacterial RNA polymerase subunits (e.g.