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Example sentences for: sbca

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In this work, we employed the pulsed-field gel electrophoresis procedure to measure large non-circular forms of the chromosome obtained from various recombination-defective mutants in rec +, recBC sbcA , and recBC sbcBC genetic backgrounds.
The accumulation of the non-circular, broken chromosomes correlated with the growth rate or DNA damage response in most of the recBC -minus background [ 30 ] . The recB or recC null mutation showed low viability even in the absence of exogenous DNA damage [ 31 32 ] . A simple interpretation of these data is that RecA, RecFOR, and RecQJ functions (and RecET functions for the sbcA background) repair chromosome breakage and/or prevent generation of the breakage.
In the recBC sbcA and the recBC sbcBC backgrounds, the absence of RecBCD nuclease may prevent faster degradation of the large non-circular DNAs.
The accumulation by the recJ mutation in the recBC sbcA background is suppressed by a recQ mutation (Figure 2C).
[ 26 ] found that both sensitivity to DNA damaging agents and decreased association of crossing-over with double-strand break repair in a recBC sbcA recJ strain are suppressed by mutant recQ alleles.