Words similar to ryr
Example sentences for: ryr
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This was shown here by the behavior of the fs-α 1S construct and elsewhere by expressing the N-terminal half (α 1S 1-670) and the C-terminal half (α 1S 701-1873), each with entirely wt sequence and each in a separate expression vector [ 20 ] . The fact that Thr671-Leu690 region known as Peptide A [ 15 ] is missing in fs-α 1S suggests this 20-mer domain is not critical for the conformation change transmitted from the DHPR to the RyR1.
4B, we failed to detect EC coupling in these KO cells transfected with fs-α 1S . In summary, the EC coupling expressed by fs-α 1S is strictly skeletal-type and requires RyR1 and DHPR β1a.
The mechanism by which the DHPR signals the RyR1 is poorly understood [ 12 13 ] . Domains in the cytoplasmic linker between repeats II and III have been clearly implicated [ 14 15 16 17 18 19 ] , and some regions such as Thr671-Lue690 were suggested to trigger RyR1 opening by binding to RyR1 [ 15 ] . However, extensive deletions within the II-III linker that eliminate the RyR1 binding region, and other suggested signaling regions in the II-III loop [ 16 ] , do not entirely eliminate EC coupling [ 20 21 ] . Hence additional domains of α 1S and/or other DHPR subunits appear to be engaged by the voltage sensor and contribute to an EC coupling signal.
The cytoplasmic loop between repeats II and III of the α 1S subunit interacts closely with RyR1 and is an important determinant of skeletal type EC coupling [ 4, 5].
The C-terminus of the β 1a subunit has also been shown to be important in EC coupling, presumably by interaction with RyR1 [ 15].
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