Words similar to ryr

Example sentences for: ryr

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4B, we failed to detect EC coupling in these KO cells transfected with fs-α 1S . In summary, the EC coupling expressed by fs-α 1S is strictly skeletal-type and requires RyR1 and DHPR β1a.
Hence the signaling mechanism, like that reported in normal myotubes and dysgenic myotubes expressing wt-α 1S , was Ca 2+entry independent [ 29 ] . We also expressed fs-α 1S in cultured myotubes from two available gene knock-out (KO) mice, lacking the endogenous β1a isoform of the skeletal muscle DHPR [ 30 ] and lacking RyR1 [ 31 ] . As shown in Fig.
For example, a region of RyR1 has been shown to be essential for L-type Ca 2+current expression [ 38].
Interactions between these two modules are likely to be critical for intramembrane charge movements in the assembled four-repeat channel and for coupling the movement of the S4 gating charges to the opening of the RyR1 channel.
Subsequent to charge movements in the voltage sensors, a conformational change in the DHPR is transmitted to the ryanodine receptor (RyR1), presumably, via protein-protein interactions [ 8 ] . Ultimately, there is a brief opening of the RyR1 channel resulting in the release of Ca 2+from the sarcoplasmic reticulum (SR).