Words similar to ryr

Example sentences for: ryr

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This was shown here by the behavior of the fs-α 1S construct and elsewhere by expressing the N-terminal half (α 1S 1-670) and the C-terminal half (α 1S 701-1873), each with entirely wt sequence and each in a separate expression vector [ 20 ] . The fact that Thr671-Leu690 region known as Peptide A [ 15 ] is missing in fs-α 1S suggests this 20-mer domain is not critical for the conformation change transmitted from the DHPR to the RyR1.
The cytoplasmic loop between repeats II and III of the α 1S subunit interacts closely with RyR1 and is an important determinant of skeletal type EC coupling [ 4, 5].
Hence the signaling mechanism, like that reported in normal myotubes and dysgenic myotubes expressing wt-α 1S , was Ca 2+entry independent [ 29 ] . We also expressed fs-α 1S in cultured myotubes from two available gene knock-out (KO) mice, lacking the endogenous β1a isoform of the skeletal muscle DHPR [ 30 ] and lacking RyR1 [ 31 ] . As shown in Fig.
This result is entirely consistent with the identification of the II-III loop as critical for enhancement of L-type Ca 2+current expression by the RyR1 [ 38 ] . However EC coupling, per se, can clearly proceed with a cut in the II-III loop.
The C-terminus of the β 1a subunit has also been shown to be important in EC coupling, presumably by interaction with RyR1 [ 15].