Words similar to ryr

Example sentences for: ryr

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The C-terminus of the β 1a subunit has also been shown to be important in EC coupling, presumably by interaction with RyR1 [ 15].
Further, the interactions between DHPR subunits and RyR1 also are incompletely understood.
The mechanism by which the DHPR signals the RyR1 is poorly understood [ 12 13 ] . Domains in the cytoplasmic linker between repeats II and III have been clearly implicated [ 14 15 16 17 18 19 ] , and some regions such as Thr671-Lue690 were suggested to trigger RyR1 opening by binding to RyR1 [ 15 ] . However, extensive deletions within the II-III linker that eliminate the RyR1 binding region, and other suggested signaling regions in the II-III loop [ 16 ] , do not entirely eliminate EC coupling [ 20 21 ] . Hence additional domains of α 1S and/or other DHPR subunits appear to be engaged by the voltage sensor and contribute to an EC coupling signal.
The cytoplasmic loop between repeats II and III of the α 1S subunit interacts closely with RyR1 and is an important determinant of skeletal type EC coupling [ 4, 5].
Subsequent to charge movements in the voltage sensors, a conformational change in the DHPR is transmitted to the ryanodine receptor (RyR1), presumably, via protein-protein interactions [ 8 ] . Ultimately, there is a brief opening of the RyR1 channel resulting in the release of Ca 2+from the sarcoplasmic reticulum (SR).