Words similar to ryr

Example sentences for: ryr

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Hence the signaling mechanism, like that reported in normal myotubes and dysgenic myotubes expressing wt-α 1S , was Ca 2+entry independent [ 29 ] . We also expressed fs-α 1S in cultured myotubes from two available gene knock-out (KO) mice, lacking the endogenous β1a isoform of the skeletal muscle DHPR [ 30 ] and lacking RyR1 [ 31 ] . As shown in Fig.
The mechanism by which the DHPR signals the RyR1 is poorly understood [ 12 13 ] . Domains in the cytoplasmic linker between repeats II and III have been clearly implicated [ 14 15 16 17 18 19 ] , and some regions such as Thr671-Lue690 were suggested to trigger RyR1 opening by binding to RyR1 [ 15 ] . However, extensive deletions within the II-III linker that eliminate the RyR1 binding region, and other suggested signaling regions in the II-III loop [ 16 ] , do not entirely eliminate EC coupling [ 20 21 ] . Hence additional domains of α 1S and/or other DHPR subunits appear to be engaged by the voltage sensor and contribute to an EC coupling signal.
4B, we failed to detect EC coupling in these KO cells transfected with fs-α 1S . In summary, the EC coupling expressed by fs-α 1S is strictly skeletal-type and requires RyR1 and DHPR β1a.
For example, a region of RyR1 has been shown to be essential for L-type Ca 2+current expression [ 38].
The cytoplasmic loop between repeats II and III of the α 1S subunit interacts closely with RyR1 and is an important determinant of skeletal type EC coupling [ 4, 5].