Words similar to ryr

Example sentences for: ryr

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Interactions between these two modules are likely to be critical for intramembrane charge movements in the assembled four-repeat channel and for coupling the movement of the S4 gating charges to the opening of the RyR1 channel.
4B, we failed to detect EC coupling in these KO cells transfected with fs-α 1S . In summary, the EC coupling expressed by fs-α 1S is strictly skeletal-type and requires RyR1 and DHPR β1a.
The cytoplasmic loop between repeats II and III of the α 1S subunit interacts closely with RyR1 and is an important determinant of skeletal type EC coupling [ 4, 5].
This was shown here by the behavior of the fs-α 1S construct and elsewhere by expressing the N-terminal half (α 1S 1-670) and the C-terminal half (α 1S 701-1873), each with entirely wt sequence and each in a separate expression vector [ 20 ] . The fact that Thr671-Leu690 region known as Peptide A [ 15 ] is missing in fs-α 1S suggests this 20-mer domain is not critical for the conformation change transmitted from the DHPR to the RyR1.
The C-terminus of the β 1a subunit has also been shown to be important in EC coupling, presumably by interaction with RyR1 [ 15].