Example sentences for: ryanodine

How can you use “ryanodine” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Subsequent to charge movements in the voltage sensors, a conformational change in the DHPR is transmitted to the ryanodine receptor (RyR1), presumably, via protein-protein interactions [ 8 ] . Ultimately, there is a brief opening of the RyR1 channel resulting in the release of Ca 2+from the sarcoplasmic reticulum (SR).

  • Calcium released via ryanodine receptors is completely sufficient to activate muscle contractions, and the effects are immediate (within milliseconds).

  • Ryanodine receptors also mediate release of Ca 2+from intracellular stores, however a previous study showed no effect of ryanodine on bitter taste responses in Necturus taste cells [ 24].

  • thapsigargin and ryanodine) deplete the ER calcium pool either by (i) inhibiting the ER calcium pump and thereby preventing the replenishment of the ER calcium pool or (ii) triggering ER (ryanodine or inositol 1,4,5-trisphosphate (IP 3 ) activated) calcium release channels [ 9 ] . These phenomena can be visualized by fluorescence microscopy as a transient increase in cytoplasmic calcium concentrations (for example see [ 10 ] ). Nominally calcium-free media are used so that the effect can be distinguished from calcium influx mediated via plasma membrane channels.

  • In the latter process, the movement of electrical charges in the α 1S subunit promotes a conformational change that opens the ryanodine receptor type-1 (RyR1) in the sarcoplasmic reticulum membrane (SR) leading to an increase in cytosolic Ca 2+[ 2, 3].


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