Words similar to runx
Example sentences for: runx
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Runx genes encode the sequence-specific DNA binding subunit of a heterodimeric transcription factor, the defining feature of which is the Runt domain, a highly conserved 128 amino acid sequence involved in DNA binding, heterodimerization, nucleotide binding, and nuclear localization [ 1 2 ] . The Runt domain is named after the first member of the family to be discovered, the regulatory gene runt from Drosophila melanogaster . Runx genes have also been discovered and functionally characterized in mammals, sea urchins and nematodes, and in general are involved in the transcriptional control of developmental processes [ 3 4 ] . In humans, mutations in each of the three Runx genes are associated with disease caused by defective control of cell proliferation and/or differentiation [ 4 5 ] . Most studies of Runx gene function and regulation have been carried out in mammals and in D. melanogaster , each of which has multiple Runx genes.
The Ciona intestinalis Runx gene was assembled with sequence files obtained from the Trace Archive database.
This intron is missing in the other Runx genes, including the sea urchin representative ( SpRunt ), and is therefore likely to be a chordate-specific feature of Runx genes that arose prior to the Runx gene duplications in the vertebrate lineage.
Three Runx genes were identified in the recently completed T. rubripes genome sequence by a TBLASTN search using the S. purpuratus Runt protein sequence as the query sequence at the Fugu BLAST Server of the UK Human Genome Mapping Project Resource Centre http://fugu.hgmp.mrc.ac.uk/blast/.
(4) The ancestor of all three vertebrate Runx genes utilized two alternative promoters that generate alternative N-terminal sequences.
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