Words similar to runt
Example sentences for: runt
How can you use “runt” in a sentence? Here are some example sentences to help you improve your vocabulary:
DmLozenge and DmRunxB ) or two ( DmRunxA ) introns separating exons N-terminal to the Runt domain, but all of these have different positions, and were thus likely to have been incorporated subsequent to the divergence of these genes.
The closest amino acid sequence similarity of any part of the Runt domain to sequences outside of metazoa is found in the motif GRSGRGKSF [ 2 ] (see Fig.
Except for the lozenge orthologues, which contain two such exons, all of the insect genes for which complete sequences are available contain only a single exon downstream of the Runt domain.
Runx genes encode the sequence-specific DNA binding subunit of a heterodimeric transcription factor, the defining feature of which is the Runt domain, a highly conserved 128 amino acid sequence involved in DNA binding, heterodimerization, nucleotide binding, and nuclear localization [ 1 2 ] . The Runt domain is named after the first member of the family to be discovered, the regulatory gene runt from Drosophila melanogaster . Runx genes have also been discovered and functionally characterized in mammals, sea urchins and nematodes, and in general are involved in the transcriptional control of developmental processes [ 3 4 ] . In humans, mutations in each of the three Runx genes are associated with disease caused by defective control of cell proliferation and/or differentiation [ 4 5 ] . Most studies of Runx gene function and regulation have been carried out in mammals and in D. melanogaster , each of which has multiple Runx genes.
The alignment of the amino acid sequences of all Runt domains used in this study was performed using the modified Clustal W [ 16 ] program in the AlignX ®module of Vector NTI (InforMax, Inc.).
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