Example sentences for: ru

How can you use “ru” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • RU 486 has recently become available in the USA for clinical use as an effective non-surgical means to induce abortion.

  • RU486 treatment of the mother noticeably protected Lifr -/- pups from bone loss (Figure 1F), although modest thinning could still be seen, suggesting that protection was incomplete.

  • Neither adrenalectomy nor RU486 treatment impact the apparent well-being of the Lifr +/+ or +/- littermates.

  • Apoptosis is considered a safeguard that enables an organ to purge itself of transformed cells [ 10 11 ] , and its inhibition is proposed as a mechanism by which non-genotoxic hepatocarcinogens produce liver cancer [ 9 23 ] . We examined the effect of RU 486 on the hepatic expression of two genes involved in the regulation of this function [ 10 11 ] , c-myc and p53, to evaluate how RU486 might inhibit apoptosis.

  • Indeed, since tumor necrosis factor alpha (TNFα) is known to suppress hepatic apoptosis [ 9 ] , a function which is considered a safeguard mechanism against neoplasia [ 10 11 ] , the reported ability of RU486 to elevate hepatic TNFα production in vivo and to enhance cell sensitivity to its toxic effects is alarming [ 12 ] . Glucocorticoids also inhibit hepatocellular proliferation [ 13 14 15 ] and modulate the expression of oncogenes and tumor suppressor genes [ 11 ] , via mechanisms involving the glucocorticoid receptor [ 16 17 18 ] , further supporting the notion that inhibiting these receptors may result in harmful effects.


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