Words similar to ru
Example sentences for: ru
How can you use “ru” in a sentence? Here are some example sentences to help you improve your vocabulary:
Because RU486 is a GR antagonist, it is known that administration can cause increased pituitary ACTH production [ 41 ] . RU486 exposure increased pituitary ACTH levels in both the Lifr +/+ and -/- animals, as judged by the apparent increase in labeling density through immunohistochemistry.
Effect of RU 486 on hepatocellular proliferation and apoptosis
Another consideration is that the benefit of RU486 administration may be either central within the HPA or can be due to peripheral GR antagonism.
Indeed, since tumor necrosis factor alpha (TNFα) is known to suppress hepatic apoptosis [ 9 ] , a function which is considered a safeguard mechanism against neoplasia [ 10 11 ] , the reported ability of RU486 to elevate hepatic TNFα production in vivo and to enhance cell sensitivity to its toxic effects is alarming [ 12 ] . Glucocorticoids also inhibit hepatocellular proliferation [ 13 14 15 ] and modulate the expression of oncogenes and tumor suppressor genes [ 11 ] , via mechanisms involving the glucocorticoid receptor [ 16 17 18 ] , further supporting the notion that inhibiting these receptors may result in harmful effects.
Nevertheless, pharmacological antagonism of glucocorticoid (type II) receptor by mifepristone (RU486) was reported to reverse high fat diet-induced obesity [ 14 ] . Since diet-induced obesity does not entail elevated glucocorticoid levels [ 15 16 17 ] , this result suggests that reduction of glucocorticoid levels would reverse obesity even when glucocorticoid levels are not elevated.
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