Words similar to rtv
Example sentences for: rtv
How can you use “rtv” in a sentence? Here are some example sentences to help you improve your vocabulary:
In the ITT: observed analysis, mean reduction in HIV-1 RNA from baseline was significantly greater at week 24 in the APV600/RTV arm than the APV1200 arm (-2.
Since the above pharmacokinetic studies and others involving pharmacokinetic modeling predictions were conducted over only a short period (generally ≤ 14 days) and in a small number of patients, there remained a need to evaluate low-dose APV/RTV combinations in large populations of HIV-1-infected patients over a therapeutically relevant period.
The greater magnitude of virologic suppression in the study population as a whole with the APV600/RTV regimen was expected in view of the results of earlier clinical pharmacokinetic studies showing a >6-fold higher C min level with APV600/RTV BID compared with the APV1200 BID regimen [ 16 ] . Higher C min values achieved with RTV-boosting may be critical in treating antiretroviral-experienced patients, particularly those with HIV isolates having increased IC 50 values.
Higher RTV doses of 200 mg BID and 400 mg BID co-administered with APV600 have resulted in no greater virologic suppression than 100 mg BID [ 25 ] , and raising the dose of APV from 600 mg BID to 900 mg BID does not improve efficacy either, although it may increase the incidence of adverse events [ 20 ] .
No differences between the APV600/RTV and APV1200 treatment arms were observed regarding the frequency of drug-related grade 1-4 adverse events (44% vs 45%), frequency of discontinuing treatment due to adverse events (7% vs 8%), incidence of hyperglycemia (1 vs 0 patient), nonspecific lipodystrophy (1 vs 0), buffalo hump (1 vs 0), or hypercholesterolemia (1 vs 0).
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