Words similar to rtv
Example sentences for: rtv
How can you use “rtv” in a sentence? Here are some example sentences to help you improve your vocabulary:
Of the 20 patients (15 in the APV600/RTV arm and 5 in the APV1200 arm) enrolled into the extension phase, 15 (11 APV600/RTV, 4 APV1200) had HIV-1 RNA <200 copies/mL at week 24.
To reduce APV pill burden and possibly improve tolerability of APV treatment, pharmacokinetic research efforts have been directed at combining APV with the PI ritonavir (RTV), which inhibits CYP3A4-mediated hepatic metabolism of APV, thereby enhancing plasma APV exposure [ 13 14 15 ] . The administration of RTV at the clinically sub-therapeutic dosage of 100 mg BID was found to boost APV plasma exposure to such a degree as to permit halving the APV daily pill burden from 16 to 8 capsules/day, in addition to maintaining the minimum plasma APV concentration (C min ) over 24 hours well above the 50% inhibitory concentrations (IC 50 ) of patient-derived HIV-1 isolates [ 15 ] . A pharmacokinetic study in 20 HIV-infected patients, PROF1004, showed that APV at the lower dosage of 600 mg BID combined with RTV 100 mg BID (APV600/RTV) resulted in a geometric mean steady-state APV C min (1.
It was lower in magnitude than the CD4+ cell count increases reported for APV600/RTV arm at 24 weeks in antiretroviral-experienced patients in ESS40006 [ 20 ] , and similar to that reported in heavily pre-treated patients by Katlama et al [ 21 ] in a patient population with comparable baseline disease characteristics (median HIV-1 RNA of 4.5 log 10 /mL and CD4+ count of 227 cells/mm 3).
In conclusion, APV600/RTV BID was similar to or better than APV1200 BID based on virologic results using the 200-copies/mL HIV-1 RNA endpoint.
Target enrollment was 198 in the APV600/RTV arm and 66 in the APV1200 arm.
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