Words similar to rtv
Example sentences for: rtv
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To reduce APV pill burden and possibly improve tolerability of APV treatment, pharmacokinetic research efforts have been directed at combining APV with the PI ritonavir (RTV), which inhibits CYP3A4-mediated hepatic metabolism of APV, thereby enhancing plasma APV exposure [ 13 14 15 ] . The administration of RTV at the clinically sub-therapeutic dosage of 100 mg BID was found to boost APV plasma exposure to such a degree as to permit halving the APV daily pill burden from 16 to 8 capsules/day, in addition to maintaining the minimum plasma APV concentration (C min ) over 24 hours well above the 50% inhibitory concentrations (IC 50 ) of patient-derived HIV-1 isolates [ 15 ] . A pharmacokinetic study in 20 HIV-infected patients, PROF1004, showed that APV at the lower dosage of 600 mg BID combined with RTV 100 mg BID (APV600/RTV) resulted in a geometric mean steady-state APV C min (1.
At week 24, the proportion of patients with HIV-1 RNA <200 copies/mL in the APV600/RTV arm and APV1200 arm was 46% (73/158) and 38% (20/53), respectively, in the ITT: M = F analysis (Figure 1) and 62% (73/118) and 53% (20/38), respectively, in the ITT: observed analysis (Figure 2).
Of the 20 patients (15 in the APV600/RTV arm and 5 in the APV1200 arm) enrolled into the extension phase, 15 (11 APV600/RTV, 4 APV1200) had HIV-1 RNA <200 copies/mL at week 24.
At week 24, the median change from baseline in CD4+ cell count in the APV600/RTV and APV1200 arms was +35 and +46 cells/mm 3, respectively, and the final median CD4+ cell count was 321 and 346 cells/mm 3, respectively.
A total of 150 patients (71%) completed all 24 weeks of the study, including a similar proportion of patients in the APV600/RTV arm (72%) and APV1200 arm (68%).
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