Words similar to ribonucleoprotein
Example sentences for: ribonucleoprotein
How can you use “ribonucleoprotein” in a sentence? Here are some example sentences to help you improve your vocabulary:
For example, Snrpn (small nuclear ribonucleoprotein N; MGI: 98347) and Snurf ( SNRPN upstream reading frame; MGI: 1891236) are expressed as bicistronic Snurf-Snrpn transcript [ 27] and both of them were associated with one single TC (TC619385) and one single DT (DT.
This finding is not anomalous because analysis of exon sequences surrounding the total set of introns in S. cerevisiae pre-mRNA genes shows a preference for AAAG at the 5' splice site [ 31 ] . The final G in this motif has been established as significantly conserved in yeast [ 32 ] . The sequence at the proximal 5' exon region is required for interactions with the spliceosomal small nuclear ribonucleoprotein particle U1 [ 19 ] . Our data are, therefore, consistent with present understanding of yeast pre-mRNA splicing.
Although direct evidence that autoantigen cleavage fragments produced during cell death elicit autoantibody responses is still scarce, Pollard et al . reported that immunization of B10.S mice (H-2 s) with a 19 kDa proteolytic cleavage fragment of fibrillarin (derived from nonapoptotic cell death) elicited antibodies that are comparable with human anti-fibrillarin autoantibodies and those derived from mice exposed to mercury [ 40 ] . In a study using human sera, Greidinger et al . reported that the recognition of apoptosis-derived and oxidatively modified forms of the 70 kDa subunit of U1 small nuclear ribonucleoprotein autoantigen was associated with distinct disease manifestations [ 41 ] . Furthermore, Oriss et al . demonstrated that a combination of antigen-processing cells and a fragment of DNA topoisomerase I efficiently elicited autoreactive T-cell proliferation, whereas the full-length topoisomerase I required additional stimulus of exogenous interleukin-2 [ 42 ] .
Transcription of these genes is followed by RNA-splicing that results in intron removal (for review, see [ 1 ] ). The majority of eukaryotic spliceosomal introns interrupt pre-mRNA in the nucleus and are removed by a ribonucleoprotein complex, termed the spliceosome.
Antibodies to CMV gB share some homology with rheumatoid factor, thus providing a theoretical relationship between CMV infection and autoimmune disease [ 12 ] . An adenovirus-CMV gB construct vaccine administered to mice induced a statistically significant increase in the production of antibodies to U1-70 kD antibody in both normal and autoimmune-prone mice [ 13 ] . Newkirk et al . recently reported an increased incidence of antibodies to Sm antigen and antibodies to ribonucleoprotein (RNP) among naturally CMV-infected individuals, as well as an increase in antibodies to U1-70 kD [ 14 ] .
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