Words similar to ribonucleoprotein
Example sentences for: ribonucleoprotein
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Although direct evidence that autoantigen cleavage fragments produced during cell death elicit autoantibody responses is still scarce, Pollard et al . reported that immunization of B10.S mice (H-2 s) with a 19 kDa proteolytic cleavage fragment of fibrillarin (derived from nonapoptotic cell death) elicited antibodies that are comparable with human anti-fibrillarin autoantibodies and those derived from mice exposed to mercury [ 40 ] . In a study using human sera, Greidinger et al . reported that the recognition of apoptosis-derived and oxidatively modified forms of the 70 kDa subunit of U1 small nuclear ribonucleoprotein autoantigen was associated with distinct disease manifestations [ 41 ] . Furthermore, Oriss et al . demonstrated that a combination of antigen-processing cells and a fragment of DNA topoisomerase I efficiently elicited autoreactive T-cell proliferation, whereas the full-length topoisomerase I required additional stimulus of exogenous interleukin-2 [ 42 ] .
Less than 10% of the patients in all groups demonstrated antibodies to SSA, SSB, dsDNA, ribonucleoprotein (RNP), and Sm.
Transcription of these genes is followed by RNA-splicing that results in intron removal (for review, see [ 1 ] ). The majority of eukaryotic spliceosomal introns interrupt pre-mRNA in the nucleus and are removed by a ribonucleoprotein complex, termed the spliceosome.
This ribonucleoprotein (RNP) complex is an endonuclease, which can initiate reverse splicing into an intron-less target site in a process known as retrohoming [ 3 ] . After the intron RNA reverse splices into one strand of the double-stranded DNA, the intron-encoded protein cleaves the other strand at position +9 or +10 downstream of the intron insertion site, and the generated 3' end of the second strand is used as a primer for reverse transcription of the inserted intron RNA.
ASSP2 is one of 12 pseudogenes of argininosuccinate synthetase encoded on 10 chromosomes with the only functional sequence residing on chromosome 9 [ 31 ] . Heterogeneous nuclear ribonucleoprotein A1 (HNRPA1) is also a pseudogene with three other copies on chromosomes 3, 13, and 20 [ 32 ] . The copy on chromosome 12q13.
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