Words similar to rhabdomyosarcoma
Example sentences for: rhabdomyosarcoma
How can you use “rhabdomyosarcoma” in a sentence? Here are some example sentences to help you improve your vocabulary:
Examples include RPs L7a, L37 and S14 in prostate tumors and cell lines [ 20 ] ; RPs L5, L7A, L18, S3, S6, S8, S12, S13, S28, P0 and P1 in colorectal cancers and cell lines [ 21 22 23 24 25 26 ] ; L5 in astrocytomas [ 27 ] ; L18a in squamous cell carcinoma [ 28 ] ; L19 in breast tumors that over-express erbB-2 [ 29 ] ; RPs S3A, S4, and S17 in lymphoid malignancies [ 30 ] ; L38, S4, P0, and P1 in rhabdomyosarcoma cell lines [ 31 ] ; and P0, P1, P2, L5, L9, L35, L39, S3A, S10, and S17 in liver tumors [ 32 ] . In addition, as noted above, a recent SAGE study identified targets of N-myc in a human neuroblastoma cell line [ 18 ] . Of 114 up-regulated genes detected, 66 encoded RPs with elevations ranging from 40% to 37-fold.
The association of ATM gene mutation/deletion with rhabdomyosarcoma suggests a link of ATM gene with cancer risk, and ATM kinase may contribute to pathogenesis of rhabdomyosarcoma.
Most cases of alveolar rhabdomyosarcoma are associated with a chromosomal translocation t(2; 13) (q35; q14), and less commonly with t(1; 13)(p36; q14) [ 6 7 8 9 ] . The t(2; 13) translocation results in fusion of a portion of the Pax3 gene to a portion of the FKHR gene, leading to formation of fusion protein Pax3-FKHR.
The levels of ATM expression in these three rhabdomyosarcoma cell lines are not identical, and Rh30 cells seemed to express less ATM than the other two Rhabdomyosarcoma cells.
Both Pax3-FKHR and Pax7-FKHR were shown to possess more potent transcriptional activity than its original forms Pax3 and Pax7 [ 10 11 ] . How the chimeric fusion proteins contribute to pathogenesis of rhabdomyosarcoma remains unclear.
Loading...