Example sentences for: rfz-

How can you use “rfz-” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The Wnt-5a/ Rfz-2 expressing C57mg cell line and the Rfz-2/β 2 AR expressing C57mg cell line were established by retroviral infections.

  • A recent report demonstrated that Wnt-5a and Rfz-2 can induce the nuclear localization of the transcription factor NF-AT [ 14 ] . Their results show that NF-AT is a downstream target of the Wnt/Ca 2+pathway and antagonizes the Wnt/beta-catenin pathway in Xenopus embryos.

  • To identify downstream genes regulated by Wnt-5a we created C57mg cells that stably express both Wnt-5a and Rfz-2, a potential ligand and receptor pair that in some assays function in the same signaling pathway.

  • The list of genes shows those that are specific to Wnt-5a/Rfz-2, differential between Wnt-5a/Rfz-2 and Wnt-1, specific to Wnt-1, and common to both Wnt-1 and Wnt-5a/Rfz-2.

  • Previous reports of ectopic expression of different Wnts in C57mg cells demonstrated Wnt-1 to be highly transforming whereas Wnt-5a failed to induce transformation [ 15 16 ] . By identifying downstream targets of Wnt-5a and Rfz-2, we wanted to determine which genes are responsible for these phenotypic changes as well as which genes might be targets of noncanonical Wnt signaling.


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