Example sentences for: rexinoids

How can you use “rexinoids” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • We have used several approaches to specifically examine the responsiveness of the CAR/RXR heterodimer to rexinoids.

  • The results described here also suggest that rexinoids may have modulatory effects on xenobiotic responses, and that such effects may differ for different CAR/RXR target genes.

  • At least one third of the 48 human members of the nuclear hormone receptor superfamily function as heterodimers with the Retinoid X Receptors, (RXRs, NR2B1-3) [ 1 ] . Some, but not all of these heterodimers can be directly activated by RXR agonists, called rexinoids, which include the endogenous ligand 9-cis-retinoic acid (9-cis-RA) and a number of synthetic compounds.

  • Direct biochemical measurements demonstrate that rexinoids can induce coactivator binding, but can also inhibit the effects of CAR agonist and inverse agonist ligands.

  • The disparities in these responses preclude a single, simple explanation for the effects of rexinoids on CAR/RXR heterodimers.


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