Words similar to rexinoids
Example sentences for: rexinoids
How can you use “rexinoids” in a sentence? Here are some example sentences to help you improve your vocabulary:
We have used several approaches to specifically examine the responsiveness of the CAR/RXR heterodimer to rexinoids.
Direct biochemical measurements demonstrate that rexinoids can induce coactivator binding, but can also inhibit the effects of CAR agonist and inverse agonist ligands.
Overall, we conclude that the disparate effects of rexinoids on CAR/RXR heterodimers in different contexts add significantly to the potential complexity of the effects of RXR ligands on such nuclear receptor heterodimers, and demonstrate that classifying a particular complex as permissive or non-permissive can be an oversimplification.
To test the effects of rexinoids on coactivator binding in a defined biochemical system, surface plasmon resonance was used to characterize the effects of the various ligands on binding of CAR, RXR and CAR/RXR heterodimers to SRC-3 (also known as ACTR, p/CIP, RAC3, AIB1, TRAM-1), an effective coactivator for CAR and many other members of the nuclear receptor superfamily.
Overall, these results significantly increase the potential complexity of the response of RXR heterodimers to RXR ligands and suggest a potential modulatory effect of rexinoids on xenobiotic responses.
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