Example sentences for: rexinoids

How can you use “rexinoids” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • We have used several approaches to specifically examine the responsiveness of the CAR/RXR heterodimer to rexinoids.

  • Direct biochemical measurements demonstrate that rexinoids can induce coactivator binding, but can also inhibit the effects of CAR agonist and inverse agonist ligands.

  • Overall, we conclude that the disparate effects of rexinoids on CAR/RXR heterodimers in different contexts add significantly to the potential complexity of the effects of RXR ligands on such nuclear receptor heterodimers, and demonstrate that classifying a particular complex as permissive or non-permissive can be an oversimplification.

  • To test the effects of rexinoids on coactivator binding in a defined biochemical system, surface plasmon resonance was used to characterize the effects of the various ligands on binding of CAR, RXR and CAR/RXR heterodimers to SRC-3 (also known as ACTR, p/CIP, RAC3, AIB1, TRAM-1), an effective coactivator for CAR and many other members of the nuclear receptor superfamily.

  • Overall, these results significantly increase the potential complexity of the response of RXR heterodimers to RXR ligands and suggest a potential modulatory effect of rexinoids on xenobiotic responses.


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