Words similar to rexinoids
Example sentences for: rexinoids
How can you use “rexinoids” in a sentence? Here are some example sentences to help you improve your vocabulary:
Direct biochemical measurements demonstrate that rexinoids can induce coactivator binding, but can also inhibit the effects of CAR agonist and inverse agonist ligands.
These results show that the negative effects of rexinoids on TCPOBOP and androstanol signaling observed with the DR-5 site from the RARβ promoter are not observed with the DR-4 and ER-6 sites from the CYP promoters.
Overall, we conclude that the disparate effects of rexinoids on CAR/RXR heterodimers in different contexts add significantly to the potential complexity of the effects of RXR ligands on such nuclear receptor heterodimers, and demonstrate that classifying a particular complex as permissive or non-permissive can be an oversimplification.
Initial functional results suggested that transactivation by CAR/RXR heterodimers is not affected by RXR ligands, including 9-cis-RA or synthetic rexinoids, indicating that CAR is a non-permissive RXR partner.
Effects of rexinoids on CAR responses to agonist and inverse agonist ligands in cells