Words similar to rexinoids

Example sentences for: rexinoids

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To test the effects of rexinoids on coactivator binding in a defined biochemical system, surface plasmon resonance was used to characterize the effects of the various ligands on binding of CAR, RXR and CAR/RXR heterodimers to SRC-3 (also known as ACTR, p/CIP, RAC3, AIB1, TRAM-1), an effective coactivator for CAR and many other members of the nuclear receptor superfamily.
Effects of rexinoids on CAR responses to agonist and inverse agonist ligands in cells
These results show that the negative effects of rexinoids on TCPOBOP and androstanol signaling observed with the DR-5 site from the RARβ promoter are not observed with the DR-4 and ER-6 sites from the CYP promoters.
The results described here also suggest that rexinoids may have modulatory effects on xenobiotic responses, and that such effects may differ for different CAR/RXR target genes.
Further characterization of potential CAR cofactors, as well as the development of sensitive and direct ligand binding assays will be required to define the molecular mechanisms that account for the diverse effects of rexinoids on CAR transactivation.