Words similar to rexinoid

Example sentences for: rexinoid

How can you use “rexinoid” in a sentence? Here are some example sentences to help you improve your vocabulary:

These rexinoid responses share the general theme of inhibition of some of the effects of CAR ligands by RXR ligands, but are clearly quite disparate.
The rexinoid alone has no effect on transactivation of the βRARE, but strongly inhibits responses to both the agonist TCPOBOP and the inverse agonist androstanol.
In transient transfections, the rexinoid LG1069 shows different effects on the ability of the xenobiotic receptor to transactivate various response elements.
Recent results suggest that the C-terminal helix 12 of RXR exerts allosteric effects on RAR function [ 6 ] . However, additional studies suggest that corepressor binding to the apo-RAR component of the heterodimer blocks rexinoid induced binding of coactivators to RXR [ 7 ] . These results suggest that the mechanisms that account for the lack of responsiveness of the non-permissive complexes are complex.
A number of RXR heterodimer complexes have been categorized as either permissive or non-permissive based on their responses to RXR ligands [ 1 ] . Although there are some reported discrepancies, the PPAR, FXR and NGF-IB/NURR1 complexes are generally considered permissive, while the non-permissive group includes the RAR, TR and VDR complexes (see [ 2 3 4 5 6 7 ] ). In the permissive complexes, coactivators can presumably bind to the AF-2 surface of both partners and binding to the RXR partner is stimulated by rexinoid agonists.