Words similar to rexinoid

Example sentences for: rexinoid

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In this context, the rexinoid blocks activation by the agonist TCPOBOP.
A number of RXR heterodimer complexes have been categorized as either permissive or non-permissive based on their responses to RXR ligands [ 1 ] . Although there are some reported discrepancies, the PPAR, FXR and NGF-IB/NURR1 complexes are generally considered permissive, while the non-permissive group includes the RAR, TR and VDR complexes (see [ 2 3 4 5 6 7 ] ). In the permissive complexes, coactivators can presumably bind to the AF-2 surface of both partners and binding to the RXR partner is stimulated by rexinoid agonists.
These rexinoid responses share the general theme of inhibition of some of the effects of CAR ligands by RXR ligands, but are clearly quite disparate.
The rexinoid alone has no effect on transactivation of the βRARE, but strongly inhibits responses to both the agonist TCPOBOP and the inverse agonist androstanol.
Initial studies were based on a well characterized binding site for CAR/RXR heterodimers, the DR-5 element from the promoter of the retinoic acid receptor β2 isoform [ 8 9 16 ] . In agreement with the biochemical results, the rexinoid blocked both the stimulatory effect of the agonist and the inhibitory effect of the inverse agonist on this element (Fig.