Words similar to rexinoid

Example sentences for: rexinoid

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The rexinoid responsive complexes are referred to as permissive and include the Peroxisome Proliferator Activated Receptor (PPAR) and the Farnesoid X Receptor (FXR) heterodimers; the Retinoic Acid Receptor (RAR), and Thyroid Hormone Receptor (TR) heterodimers are non-permissive [ 2 3 4 5 6 7 ] .
These rexinoid responses share the general theme of inhibition of some of the effects of CAR ligands by RXR ligands, but are clearly quite disparate.
Initial studies were based on a well characterized binding site for CAR/RXR heterodimers, the DR-5 element from the promoter of the retinoic acid receptor β2 isoform [ 8 9 16 ] . In agreement with the biochemical results, the rexinoid blocked both the stimulatory effect of the agonist and the inhibitory effect of the inverse agonist on this element (Fig.
In this context, the rexinoid blocks activation by the agonist TCPOBOP.
In transient transfections, the rexinoid LG1069 shows different effects on the ability of the xenobiotic receptor to transactivate various response elements.