Words similar to rexinoid

Example sentences for: rexinoid

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A number of RXR heterodimer complexes have been categorized as either permissive or non-permissive based on their responses to RXR ligands [ 1 ] . Although there are some reported discrepancies, the PPAR, FXR and NGF-IB/NURR1 complexes are generally considered permissive, while the non-permissive group includes the RAR, TR and VDR complexes (see [ 2 3 4 5 6 7 ] ). In the permissive complexes, coactivators can presumably bind to the AF-2 surface of both partners and binding to the RXR partner is stimulated by rexinoid agonists.
To examine the effects of RXR ligands on CAR transactivation in a more functional context, the rexinoid LG1069 was combined with the CAR inverse agonist androstanol and the agonist TCPOBOP in a series of transient transfection studies using different response elements.
To test whether the apparent allosteric effects of LG1069 on CAR transactivation vary with different response elements, the effect of the rexinoid on transactivation directed by cytochrome P450 response elements was examined.
These rexinoid responses share the general theme of inhibition of some of the effects of CAR ligands by RXR ligands, but are clearly quite disparate.
The rexinoid alone has no effect on transactivation of the βRARE, but strongly inhibits responses to both the agonist TCPOBOP and the inverse agonist androstanol.