Words similar to relevance
Example sentences for: relevance
How can you use “relevance” in a sentence? Here are some example sentences to help you improve your vocabulary:
In order to preserve post-Cold War relevance, the alliance needs 1) tight European-American cooperation; 2) beefed-up European responsibility for security; and 3) continued expansion of membership to Eastern European nations.
Interestingly, both IFN-γ and TNF-α are prominent in the pathogenesis of autoimmune diseases in general; the former by activation of local auto antigen presentation to appropriate T cells, and the latter by mediation of inflammatory tissue damage [ 68 ] . Apparently TNF-α plays a central role in the chronic release of highly arthritogenic II-1 [ 69 ] , and thus serves as a major factor in the pathogenesis of rheumatoid arthritis (RA) [ 69 ] . Recent studies show that treatment with anti-TNF-α gives significant clinical improvement in RA [ 70 ] . Thus our findings in aged individuals of a prominent CD8 +CD28 -T cell subset with enhanced ability to produce TNF-α, may assume clinical relevance.
Criterion 2 addresses the biological relevance of a hit (e.g.
Bacteria are found in the bile of the gallbladder and bile ducts [ 15 16 ] , the presence of which may have relevance to clinical diseases such as stone formation [ 19 20 21 ] , primary sclerosing cholangitis [ 22 ] , and cholestasis [ 23 24 ] . Direct exposure of sub-epithelial tissue to LPS from gram-negative bacteria causes release of cytokines by resident leukocytes and activation of macrophages [ 25 ] . The biliary fluid of patients with cholangitis has increased concentrations of the inflammatory cytokines TNF-α and IL-6 suggesting that bacterial infection leads to an increase in cytokines released into the bile [ 26 ] . Adding LPS to the bile of guinea pig gallbladders in vivo led to increased IL-1 concentration in the bile [ 27 ] . What role biliary epithelial cells play in the response to bacteria in bile is not known.
However, if interest lies primarily in the recognition of an unknown classification of the data, an artificial clustering is not satisfactory, and clusters resulting from the algorithm must be investigated for their relevance and reproducibility.
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