Words similar to receptor
Example sentences for: receptor
How can you use “receptor” in a sentence? Here are some example sentences to help you improve your vocabulary:
The dominance of Ang-2 over Ang-1 mRNA and protein in OA synovial tissue are in agreement with the inactive VEGF receptor 1 pathway (angiogenic pathway) in OA [ 24 ] . The Ang-2 mRNA expression pattern correlates with the Ang-2 immunostaining detected on endothelial cells.
C/EBP is previously reported to be an important accessory factor for transactivation by several other transcription factors [ 26 ] . C/EBPβ was shown to transactivate the α1-acid glycoprotein gene promoter even when mutated in the DNA-binding domain, and this activation appeared to depend on protein-protein interaction with glucocorticoid receptor through the leucine zipper region [ 27 ] . Recently, a conserved domain in C/EBPα and C/EBPβ was shown to mediate cAMP responsiveness, strengthening the fact that C/EBP may be characterized as a cAMP-responsive nuclear regulator [ 28 29 ] . On the COX-2 promoter in granulosa cells, cAMP-mediated regulation was shown to be mediated primarily by an E-box that bind USF1 and USF2 isoforms in a manner resembling the RIIβ E-box in Sertoli cells [ 30 ] . Transactivation of the COX-2 gene in skin carcinoma cells is highly dependent on this E-box together with a C/EBP binding site that bind C/EBPβ and C/EBPδ [ 31 ] . These data strengthens a model of formation of a cAMP-responsive unit (CRU) containing USF and C/EBP.
Interestingly, by simply replacing Smad1 with the Smad1 mutant Smad1G419S [ 40 ] , which is defective in binding to BMP type I receptor for receptor-mediated phosphorylation and the subsequent nuclear translocation, SNIP1 degradation was also inhibited (Fig.
Distinct nAChR subtypes exist that can be stimulated by the neurotransmitter acetylcholine, the natural product nicotine, or by synthetic compounds [ 1 ] . nAChR is the prototype for a protein superfamily that includes the receptors for the excitatory amino acids glutamate and aspartate, the inhibitory amino-acids gamma-aminobutyric acid (GABA) and glycine, as well as the serotonin 5-HT 3 receptor [ 1 ] . Like most ligand-gated ion channels, nAChRs are homo- or hetero-pentameric, each monomer belonging to a pull of 8 alpha- or 3 beta-subunits (alpha 2-9 , beta 2-4 ). While each subunit has four transmembrane domains, the agonist binding sites are located at the subunit interfaces [ 2 ] . Both natural and synthetic ligands can display varied affinity for different receptor subtypes.
In particular, inhibitors of TNF-α and IL-1 have proven effective in clinical trials, and the US Food and Drug Administration has approved the use of soluble TNF-α receptor for treatment of human RA.
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