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Example sentences for: rdta

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Western blots analyses demonstrate that the amounts of NR1, NR2A/B and β-actin are significantly increased in the retinae of rdta mice compared to their littermate controls.
Because CaMKII expression/activity is up-regulated in the rdta retina [ 34] and because GluR1 is a substrate of CaMKII [ 36, 37, 38, 39, 40], the increased phosphorylation of GluR1 seen here in the retinal synapses of the rdta mice could indicate a synergy between CaMKII and GluR1.
Because GluR1 is a known substrate of CaMKII in vitro and in vivo [ 34, 36, 37, 38, 39, 40] and because CaMKII expression/activity is up-regulated in the retinae of the rdta mice [ 34], GluR1 phosphorylation might also be increased in the rodless retina.
NR1 expression and NR2A/B composition are altered in the rdta retina
While stimulation of PKC activity may decrease CaMKII binding to the NMDA receptor complex [ 56], there is no change in the level of PKC in the rdta mice [ 34].