Example sentences for: rapamycin

How can you use “rapamycin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Rapamycin completely abolished the phosphorylation of Thr389 in p70 S6 kinase in insulin-treated cells and also abolished the basal phosphorylation of p70 S6 kinase in control cells, at both time points examined (Fig.

  • H441 cells resemble bronchiolar epithelial Clara cells in phenotype and produce both SP-A and SP-B mRNA and protein [ 14 ] . The hormonal regulation of SP-A and SP-B gene expression in H441 cells is similar to that observed in differentiated type II cells in human fetal lung explants [ 6 7 15 16 ] . We treated H441 cells with the four inhibitors of signal transduction: wortmannin, LY294002, rapamycin and PD98059, to elucidate which signaling pathways are activated when insulin inhibits SP-A gene expression.

  • Clinical trials using the rapamycin analog CCI-779 show promise for this strategy [ 22 ] . Rapamycin and its synthetic analogs block mTOR kinase activity leading to dephosphorylation of 4EBP and other mTOR substrates.

  • Effect of concomitant tacrolimus and rapamycin therapy on lymphocyte proliferation

  • In addition, and somewhat ironically, the most commonly used agents (like steroids, calcineurin inhibitors, and rapamycin) are also known to impair normal islet function and/or insulin action.


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