Words similar to rapamycin
Example sentences for: rapamycin
How can you use “rapamycin” in a sentence? Here are some example sentences to help you improve your vocabulary:
The small molecule rapamycin has been transcriptionally profiled by three research groups in four separate studies [ 4, 11, 21, 22].
Insulin transduces its cellular signal in most cell types via two signaling pathways, i.e., the p44/42 mitogen-activated protein kinase (MAPK) pathway and the phosphatidylinositol 3-kinase (PI 3-kinase) pathway [ 8 ] . Insulin initially binds to the insulin receptor causing autophosphorylation of the β-subunit of the receptor [ 8 ] . The protein kinase domain of the β-subunit then phosphorylates tyrosine residues in insulin receptor substrate (IRS)-1, IRS-2, IRS-3, or Shc, which then activates the p44/42 MAPK signaling cascade [ 8 ] . PD98059 is a cell permeable, non-competitive, reversible inhibitor of MAPK/extracellular signal-regulated kinase kinase (MEK), a protein kinase upstream of p44/42 MAPK [ 9 ] . Tyrosine phosphorylated IRS also activates the PI 3-kinase pathway [ 8 10 ] . There are at least three, well-characterized inhibitors of the PI 3-kinase pathway, i.e., wortmannin, LY294002, and rapamycin [ 11 12 13 ] . Wortmannin and LY294002 block the activation of PI 3-kinase itself [ 11 12 ] , while rapamycin prevents the phosphorylation of a downstream effector in the pathway, p70 S6 kinase [ 13 ] .
Rapamycin also down regulated the Thr421/Ser424 phosphorylation in p70 S6 kinase in control and insulin-treated cells at both time-points (Fig.
Against the same set of 300 diverse expression profiles described earlier [ 19], not a single vector could be found that had an angle less than 60° with the rapamycin experiment vector (data not shown).
Effect of concomitant tacrolimus and rapamycin therapy on gene expression in lymphocytes
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