Words similar to rapamycin

Example sentences for: rapamycin

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Rapamycin also down regulated the Thr421/Ser424 phosphorylation in p70 S6 kinase in control and insulin-treated cells at both time-points (Fig.
Rapamycin completely abolished the phosphorylation of Thr389 in p70 S6 kinase in insulin-treated cells and also abolished the basal phosphorylation of p70 S6 kinase in control cells, at both time points examined (Fig.
Rapamycin inhibits activation of p70 S6 kinase, a downstream effector in the PI 3-kinase signaling pathway [ 13 ] . Rapamycin forms a complex with FK506-binding protein 12 and this complex blocks the kinase activity of mTOR (mammalian target of rapamycin), a kinase upstream of p70 S6 kinase [ 20 ] . The IC 50 for p70 S6 kinase inhibition by rapamycin is ~0.
If rapamycin and its analogs are to be developed as useful antitumor agents, it will be important to determine how p27 Kip1levels affect responsiveness to these compounds.
The cultured cells were subsequently exposed to fresh serum-free media and pretreated for 30-60 minutes with either control media that contained the vehicle for the inhibitors (dimethyl sulphoxide) or with media that contained wortmannin (5-200 nM), LY294002 (2-50 μM), rapamycin (1-100 nM), or PD98059 (2.