Words similar to rankl

Example sentences for: rankl

How can you use “rankl” in a sentence? Here are some example sentences to help you improve your vocabulary:

GST-RANKL was purified as described previously [ 32 ] . Briefly, a fragment of murine RANKL cDNA was cloned inframe into the pGEX-4T vector (Amersham Pharmacia, Piscataway, USA) and expressed in BL21 bacteria (Amersham Pharmacia) induced with 0.1 mM IPTG (Gibco) for 5 hours at 30°C.
In the present study, we demonstrate that early exposure to RANKL renders osteoclast precursors resistant to the effects of IFN-γ, including inhibition of osteoclastogenesis.
Fusion and multinucleation subsequently occurred in proportion to the magnitude of the RANKL stimulus.
These data may help explain the contradictory findings regarding the effects of IFN-γ as an inhibitor of osteoclastogenesis, and also suggest a model of erosive disease in the presence of IFN-γ whereby osteoclast precursors are exposed to RANKL before they enter the IFN-γ-rich environment.
Together these data show that pretreatment with RANKL increases resistance to IFN-γ-mediated osteoclast inhibition in a dose-dependent and time-dependent manner.