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Example sentences for: rankl

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The potency of IFN-γ as a macrophage activator and osteoclast inhibitor suggests a prominent role for T cells and/or NK cells in the regulation of bone resorption, as these cells constitute the major source of IFN-γ [ 18 ] . A link between activated T cells and osteoclast inhibition by IFN-γ has been highlighted in a report by Takayanagi et al ., providing the first in vivo evidence that the immune system may influence osteoclastogenesis [ 38 ] . Interestingly, other groups have demonstrated that activated T cells induce osteoclastogenesis via upregulation of surface RANKL, presenting a dilemma regarding the role of activated T cells in osteoclastogenesis [ 20 40 45 ] .
We failed to observe significant degradation of TRAF6 after stimulation with IFN-γ or RANKL in short-term or long-term cultures (Fig.
Pretreatment with RANKL inhibited IFN-γ-induced NO production in a dose-dependent and time-dependent manner (Fig.
Pretreatment with lower doses of RANKL was unable to overcome IFN-γ inhibition, indicating that resistance to IFN-γ required high levels of RANKL pretreatment (Fig.
Bone-resident macrophages pre-exposed to RANKL in the stromal environment may be resistant to the immunoregulatory effects of IFN-γ, and may thus be better suited for bone-remodeling tasks.