Words similar to rankl

Example sentences for: rankl

How can you use “rankl” in a sentence? Here are some example sentences to help you improve your vocabulary:

The strength of the early RANKL signal may be altered in the setting of inflammatory bone diseases such as rheumatoid arthritis, in which high levels of RANKL expressed on either synovial cells or infiltrating T cells [ 43 44 ] may induce osteoclast formation despite the presence of exogenous or endogenous IFN-γ.
Consistent with our prior results, concomitant treatment of IFN-γ and RANKL showed dominance of the IFN-γ upregulation, while pretreatment with RANKL for 2 days showed impaired upregulation.
In contrast, Wei et al . have demonstrated that pre-osteoclasts do not lose their potential to differentiate into mature osteoclasts following a similar exposure to IL-4 [ 50 ] . It thus appears that IFN-γ anti-osteoclast activity is mediated by inducing terminal differentiation away from the osteoclast lineage, while IL-4 directly interferes with RANKL signaling during osteoclastogenesis.
The present results predict that IFN-γ will not activate these cells, as they have received an early RANKL signal.
A dose of 200 ng/ml RANKL generated numerous large, multinucleated osteoclasts.