Words similar to purinergic

Example sentences for: purinergic

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The cluster shown in Figure 6cis composed of members of two genes families: adenosine receptors (ADORA3 and ADORA2A) and purinergic receptors (P2RX1 and P2RX7).
Recent studies have shown that maitotoxin (MTX), a potent cytolytic agent isolated from the dinoflagellate Gambierdiscus toxicus, is an important new molecular tool for the study of oncotic (necrotic) cell death [ 1 2 ] . In a variety of cell types, MTX initiates a cell death cascade that involves a sequence of cellular events essentially identical to those activated by stimulation of purinergic receptors of the P2Z/P2X 7 type.
Stimulation of P2X purinergic receptors by ATP causes similar changes in cytosolic Ca 2+and vital dye uptake [ 10, 11, 12, 13, 14, 15, 16, 17] suggesting that MTX activates a cell death cascade that is physiologically relevant, although the exact role of either the P2X- or MTX-induced cascade in normal cellular biology remains unknown.
Previous studies suggested that ATP-induced pores in HEK cells heterologously expressing the P2X 7 purinergic receptor, were formed either by dilation of the channel structure or by aggregation of channels subunits [ 19].
This could explain the temperature sensitivity of vital dye uptake, previously noted for both MTX- [ 8, 9] and purinergic receptor-induced [ 12, 15] vital dye uptake.