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Example sentences for: pufas
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The inability of cancer cells to maintain the activity of GPX in the presence of a diet containing n-3 PUFAs was related to increased oxidative damage to membrane lipids and to significant enhancement of the efficacy of DOX therapy.
The results of cell culture and animal studies have shown that omega 3 polyunsaturated fatty acids (n-3 PUFAs) selectively killed cancer cells in vitro [ 1 ] . Furthermore, n-3 PUFAs incorporated into animal diets have reduced tumor growth rates in vivo [ 2 3 4 ] . The prevailing hypothesis for the reduction in tumor cell growth, in vitro or in vivo , by supplementing the diet with high levels of n-3 PUFAs has been that the incorporation of n-3 PUFAs into cell membranes of the tumor cells increased the susceptibility of the cells for lipid peroxidation and that the products of lipid peroxidation subsequently accumulated to cytostatic or cytotoxic levels [ 2 5 6 7 ] . It has also been reported that supplementing the diet of cancer xenograft bearing mice with n-3 PUFAs could increase the efficacy of edelfosine [ 8 ] , doxorubicin [ 9 ] , mitomycin [ 10 ] , cyclophosphomide and 5-fluorouracil [ 11 ] or irinotecan [ 12 ] against the tumor.
An important aspect of the present study was that the n-3 PUFAs dietary supplement be fed to mice at a level that humans could readily consume.
These results indicate that n-3 PUFAs in the diet are incorporated in cell membranes, increasing the polyunsaturation of the membrane and increasing the susceptibility for lipid peroxidation.
However, when the diet was relatively low in omega-3 PUFAs, the promotional effect of vitamin E was not observed [ 8 ] . It is noteworthy that the diet used in the presently reported study was very low in omega-3 PUFAs and that this diet, combined with the high dietary level of sE, resulted in suppression of tumor growth.
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