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Example sentences for: ptr
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We then defined the inversion breakpoint interval as the region between the most distal probe on HSA 15q to display a PTR XVp signal, RP11-360J18 and the most proximal probe on HSA 15q to display a PTR XVq signal, RP11-736I24 (Figure 3).
Interestingly, the segmental duplications identified in this analysis were confined to the 600 kb covered by the clones which produced the dual FISH signals in PTR.
We next investigated the nature of the sequence underlying the pericentric inversion breakpoint by extracting the 1 Mb interval encompassing the sequence between the most distal PTR XVp probe, RP11-360J18, and the most proximal PTR XVq probe, RP11-736I24, from the November 2002 human genome assembly.
Our FISH results using probe RP11-40J8, which demonstrated dual signals on PTR XVp and XVq, indicated we had reached the site of the pericentric inversion, or alternatively a sequence within RP11-40J8 had been duplicated to both arms of PTR XV.
Primarily examined through the use of G-banding cytogenetic techniques, the human and common chimpanzee karyotypes differ by only 10 euchromatic rearrangements: a telomere fusion between PTR chromosomes 12 and 13, resulting in HSA chromosome 2, and 9 pericentric inversions (HSA 1, 4, 5, 9, 12, 15, 16, 17, 18) [ 1 2 ] . The predominance of pericentric inversions between chimps and humans highlights their potential importance in the divergence of human from non-human primate species, and provides an opportunity to investigate the mechanism facilitating these rearrangements.
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