Words similar to psoriasis
Example sentences for: psoriasis
How can you use “psoriasis” in a sentence? Here are some example sentences to help you improve your vocabulary:
Six patients (4M, 2F) with stable plaque psoriasis were recruited for study.
Skin antigen-presenting cells (Langerhans cells) appear to play an important role in the initiating events that lead to the cytokine cascade that results in keratinocyte proliferation and development of psoriatic lesions [ 16 17 18 ] . Effective therapeutic approaches to psoriasis treatment, such as psoralen UV-A therapy (PUVA), which result in depletion of APCs in the skin [ 19 20 ] , and UV-B [ 21 ] , lead to one of the most sustained improvement in psoriasis.
The drugs have been studied with relation to their effect in Graves' hyperthyroidism which, like psoriasis, is an autoimmune disorder [ 9 10 11 12 ] Antithyroid thioureylenes, of which propylthiouracil, methimazole and carbimazole are used in clinical practice, have known immunomodulatory properties [ 13 14 ] and, in the case of psoriasis, also have antiproliferative effects as demonstrated by their ability to produce a decline in markers of cellular proliferation such as proliferative cell nuclear antigen (PCNA) [ 15 ] .
The present study was performed to examine the effect of propylthiouracil treatment of patients with plaque psoriasis on CD1a expression in their psoriatic lesions in order to determine whether this form of therapy resulted in depletion of APCs from affected skin, that could account for the therapeutic benefit of PTU in this disorder.
Additional studies are being performed which address whether PTU treatment of patients with plaque psoriasis leads to reduced in situ IL-12 expression, alters production of the IL-35 or IL-40 components of the IL-70 heterodimer, as well as exerts an effect by enhancing apoptosis in the proliferated keratinocytes that make up the psoriatic plaque which would result in clinical improvement.
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