Words similar to psf
Example sentences for: psf
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Our data suggests that nmt55/p54 nrbmay be critical to cell growth and function, such that, decreased nmt55/p54 nrbexpression in ER- human breast tumors or the expression of nmt55/p54 nrbvariants in ER+ tumors may indicate loss of normal growth, nmt55/p54 nrbhas been shown in several studies to bind RNA and interact with PSF and Topoisomerase I [ 14 16 17 18 19 20 39 ] . Those results along with our observations that nmt55/p54 nrbassociates with several splicing factors essential for spliceosome formation (unpublished) and relates to tumor hormonal status [ 13 ] suggest that nmt55/p54 nrbmay be involved in pre-mRNA processing.
Our studies on nmt55 and those of p54 nrbhave characterized this protein as an RNA binding protein with the ability to associate with Topoisomerase I and the polypyrimidine tract-binding protein associated splicing factor (PSF) [ 16 17 18 19 20 ] . Further, we observed the association of nmt55/p54 nrbwith several splicing factors known to be essential for spliceosome formation suggesting a role for nmt55/p54 nrbin pre-mRNA splicing (unpublished results).
TOP1 has been shown to interact with many proteins including components of the holo TFIIIC complex [ 1 ] , TFIID [ 2 ] , p53 [ 3 ] , SV-40 large T antigen [ 4 ] , nucleolin [ 5 ] , the RING finger protein topors [ 6 ] , the RNA splicing factors PSF/p54 nrb [ 7 ] and SF2/ASF [ 8 ] , the cell cycle regulatory protein ARF [ 9 ] , RNA pol II complex [ 10 11 ] , and HTLV type 1 tax oncoprotein [ 12 ] . TOP1 also interacts with a variety of unidentified proteins involved in its phosphorylation, ubiquitination and sumoylation [ 13 14 15 16 17 ] .
Two secreted proteins or protein complexes are involved in sensing cell density [ 5 ] . Prestarvation factor (PSF) is a glycoprotein that is secreted when cells are growing and accumulates as an indicator of the ratio of cell density relative to the supply of food [ 6 7 ] . When the ratio of Dictyostelium cells to nutrients is above a certain threshold, PSF induces the expression of several early developmental genes including discoidin I, lysosomal enzymes, and some components of the cAMP pulsing system [ 8 9 ] . Once nutrients are depleted, PSF production declines and a second cell density-sensing pathway is activated.
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