Example sentences for: proviral

How can you use “proviral” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Finally, there was no association between DLCO and the level of HTLV-I or HTLV-II proviral load among the HTLV seropositives (data not shown).

  • As to HIV, how can we use our knowledge of P-TEFb to slow down viral replication and/or to eliminate the state of proviral latency in the host?

  • pol -encoded protease to yield the active form of the enzyme [ 1 2 ] . This multifunctional enzyme is responsible for copying the single stranded viral RNA genome into double stranded proviral DNA [ 3 4 ] . HIV-1 RT is a heterodimer consisting of a 66 and 51 kDa polypeptide chain designated as p66 and p51, respectively.

  • Infection of cultured podocytes with replication incompetent HIV-1 demonstrated that HIV-1 gene expression leads to the proliferation and dedifferentiation of the infected podocytes [ 6 7 8 ] , recapitulating the phenotypes observed in HIVAN specimens [ 9 10 ] . Similarly, renal expression of replication incompetent HIV-1 proviral transgenes in mice and rats produces a proliferative renal lesion that is indistiguisable both histopathologically and clinically from human HIVAN [ 11 12 13 14 ] . These observations raise the possibility that HIV-1 gene products may interact with mitogenic pathways in infected renal epithelium to cause aberrant cell-cycle engagement.

  • It is not surprising that proviral latency, in which low levels of transcription or only short HIV transcripts containing TAR are observed, would in large part reflect the absence of these activators.


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