Words similar to proviral
Example sentences for: proviral
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Finally, there was no association between DLCO and the level of HTLV-I or HTLV-II proviral load among the HTLV seropositives (data not shown).
Cyclin D 1 is characterized as the major D-type cyclin controlling G 1 -phase progression in kidney cells, both during normal and abnormal proliferation [ 22 23 ] . To determine whether cyclin D 1 may be active in promoting G 1 → S progression in kidneys expressing HIV-1 genes, we utilized a well-characterized HIV-1 transgenic mouse model (Tg26) of HIVAN [ 11 12 13 ] . Secondary to renal expression of the HIV-1 NL4-3 Δ gag-pol proviral transgene, adolescent Tg26 transgenics develop a progressive, proliferative renal disease marked by podocyte and tubular epithelial hyperplasia that is indistinguishable both clinically and histopathologically from human HIVAN.
In particular, APOBEC3G targets the reverse transcription step of the HIV life cycle, in which the viral genomic RNA is converted into proviral DNA, which is then integrated into the host genome (Mangeat et al.
pol -encoded protease to yield the active form of the enzyme [ 1 2 ] . This multifunctional enzyme is responsible for copying the single stranded viral RNA genome into double stranded proviral DNA [ 3 4 ] . HIV-1 RT is a heterodimer consisting of a 66 and 51 kDa polypeptide chain designated as p66 and p51, respectively.
It is not surprising that proviral latency, in which low levels of transcription or only short HIV transcripts containing TAR are observed, would in large part reflect the absence of these activators.
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