Words similar to protα
Example sentences for: protα
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Prothymosin α (ProTα) belongs to the α-Thymosin family which comprises different polypeptides widely distributed within animal tissues.
In the U937 monocytic cell line, ProTα mRNA peaked at the end of S/G2 phase and fell towards the entry into the new G1 phase.
Although its role has remained controversial, it is involved in the increase of immediate early genes such as c-myc [ 63 ] , which is upstream of cyclin D synthesis and necessary for cell division [ 64 ] . In humans, ProTα is coded by a gene family of six members.
It has been demonstrated that malignant tissues with accelerated cell cycle show higher levels of ProTα expression than normal or surrounding healthy tissues [ 67 ] . ProTα was shown as a marker for breast cancer [ 68 ] , hepatocarcinoma [ 69 ] , and plasma levels of its derivative Tα 1 been proposed as a marker for the prognosis of lung cancer [ 70 ] . In ligand blotting assays, ProTα bound only to chromatin pools and nuclear fractions where histone H1 was present [ 71 72 ] . The analysis of the interaction of ProTα with H1-containing chromatin suggests a putative role for ProTα in the fine-tuning of the stoichiometry and/or mode of interaction of H1 with chromatin [ 73 ] . Interestingly, HL-60 cells overexpressing ProTα show an enhancement of accessibility of micrococcal nuclease to chromatin, implying relaxed chromatin structure for enhanced cell cycle gene expression [ 74 ] .
A broad study using several mononuclear and fibroblastic cell lines has shown that ProTα mRNA accumulation is cell cycle phase-dependent.
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