Words similar to protα
Example sentences for: protα
How can you use “protα” in a sentence? Here are some example sentences to help you improve your vocabulary:
Although its role has remained controversial, it is involved in the increase of immediate early genes such as c-myc [ 63 ] , which is upstream of cyclin D synthesis and necessary for cell division [ 64 ] . In humans, ProTα is coded by a gene family of six members.
In the U937 monocytic cell line, ProTα mRNA peaked at the end of S/G2 phase and fell towards the entry into the new G1 phase.
It has been demonstrated that malignant tissues with accelerated cell cycle show higher levels of ProTα expression than normal or surrounding healthy tissues [ 67 ] . ProTα was shown as a marker for breast cancer [ 68 ] , hepatocarcinoma [ 69 ] , and plasma levels of its derivative Tα 1 been proposed as a marker for the prognosis of lung cancer [ 70 ] . In ligand blotting assays, ProTα bound only to chromatin pools and nuclear fractions where histone H1 was present [ 71 72 ] . The analysis of the interaction of ProTα with H1-containing chromatin suggests a putative role for ProTα in the fine-tuning of the stoichiometry and/or mode of interaction of H1 with chromatin [ 73 ] . Interestingly, HL-60 cells overexpressing ProTα show an enhancement of accessibility of micrococcal nuclease to chromatin, implying relaxed chromatin structure for enhanced cell cycle gene expression [ 74 ] .
Prothymosin α (ProTα) belongs to the α-Thymosin family which comprises different polypeptides widely distributed within animal tissues.
A broad study using several mononuclear and fibroblastic cell lines has shown that ProTα mRNA accumulation is cell cycle phase-dependent.
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