Words similar to proapoptotic
Example sentences for: proapoptotic
How can you use “proapoptotic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Our previous study demonstrated that cultured HUVEC released annexin V-binding membrane MP in response to proapoptotic stimulation with CPT [ 3 ] . In the present study, we investigated whether endothelial cells release membrane MP after rapid stimulation with Ca 2+-mobilizing agents or after overnight stimulation with proinflammatory agents TNFα and LPS, or only after induction of apoptosis.
PH-20 induces the expression of proapoptotic p53 [ 9 ] and WOX1 (WW domain-containing oxidoreductase; also known as WWOX or FOR) [ 10 ] , which contributes to the increased TNF cytotoxic effect.
Mancini et al . reported that caspase-2 was localized at the Golgi complex and generated a unique cleavage product of golgin-160 [ 29 ] . Furthermore, these investigators proposed that the Golgi complex transduces proapoptotic signals [ 29 ] . A precedent for this hypothesis was provided by Nakagawa et al ., who reported that caspase-12 is localized to the endoplasmic reticulum and mediates an endoplasmic reticulum-specific apoptosis pathway [ 33 ] . In the present study, we have found that all Golgi autoantigens examined were cleaved in apoptosis in a caspase-dependent manner, as evidenced by studies showing that the pan-caspase inhibitor zVAD-fmk completely blocked the apoptotic fragmentation of these antigens.
These findings indicate that CD36 activates proapoptotic p38 MAPK possibly via src kinase activation in human PTECs when stimulated with AGE-BSA5 and PA.
Tumor suppression by Fhit is not destroyed by mutation of the nucleophilic His96 to Asn, a mutation that specifically reduces k cat [ 2 12 ] . Thus, evidence suggests that the proapoptotic function of Fhit depends on formation of an E-S complex.
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