Words similar to proto-oncogene

Example sentences for: proto-oncogene

How can you use “proto-oncogene” in a sentence? Here are some example sentences to help you improve your vocabulary:

The proto-oncogene TEL (Translocation, Ets, Leukemia) is a transcriptional repressor that contains a C-terminal Ets family DNA binding domain; a central domain that together with co-repressors recruit histone deacetylases [ 1 2 3 ] ; and an N-terminal SAM (sterile, alpha, motif) domain [ 4 5 6 ] , which we have recently shown forms a polymer [ 7 ] . Chromosomal translocations in a variety of leukemias result in fusion of the SAM domain of TEL to tyrosine kinase domains such as ABL, PDGFβ and JAK2 [ 8 9 10 11 12 13 14 ] or to the transcriptional activators AML1 and ARNT [ 15 16 17 ] . In the tyrosine kinase fusions, SAM domain polymerization leads to constitutive activation of the tyrosine kinase domains, which leads in turn to cell transformation [ 10 12 18 19 ] . Thus, compounds that block TEL-SAM polymerization could be effective in treating these leukemias.
The specificity of the signals driven by PMA was further stressed by the up-regulation of CD3 expression and by the unaltered mRNA levels of the proto-oncogene c-Ha-ras.
The constitutively expressed proto-oncogene c-Ha-ras was used as internal control.
Calpain activity is needed for proteolysis of the c-mos proto-oncogene product pp39 mos in Xenopus oocytes [ 51 ] , certain cytoskeletal proteins (alpha-tubulin, actin, dynamin, lamin B) in starfish oocytes [ 52 ] , and of cyclin in Xenopus egg extracts [ 53 ] .
The proto-oncogene c- myc can be upregulated by oestrogen stimulation of hormone-dependent breast cancer cells.