Example sentences for: proto-oncogene

How can you use “proto-oncogene” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The proto-oncogene c- myc can be upregulated by oestrogen stimulation of hormone-dependent breast cancer cells.

  • We previously reported that enhanced liver apoptosis in response to the antihepatocarcinogen rotenone was preceded and accompanied by a marked increase in the hepatic levels of c-myc mRNA [ 10 ] , a proto-oncogene that plays a dual role in cell proliferation and apoptosis [ 24 ] . Since in our study [ 10 ] rotenone inhibited hepatocellular proliferation while enhancing apoptosis, we concluded that the increase in c-myc mRNA expression acted as a pro-apoptotic signal in the liver.

  • Calpain activity is needed for proteolysis of the c-mos proto-oncogene product pp39 mos in Xenopus oocytes [ 51 ] , certain cytoskeletal proteins (alpha-tubulin, actin, dynamin, lamin B) in starfish oocytes [ 52 ] , and of cyclin in Xenopus egg extracts [ 53 ] .

  • The constitutively expressed proto-oncogene c-Ha-ras was used as internal control.

  • The specificity of the signals driven by PMA was further stressed by the up-regulation of CD3 expression and by the unaltered mRNA levels of the proto-oncogene c-Ha-ras.


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