Words similar to prohb-egf
Example sentences for: prohb-egf
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Detection of the physical interactions of proHB-EGF with CD9 antigens
The membrane-bound precursor and soluble forms of heparin-binding epidermal growth factor-like growth factor (HB-EGF) contribute to a variety of cellular developmental processes [ 1 ] . The observations of HB-EGF in cell and tissue types have suggested roles for HB-EGF in numerous cellular and tissue events such as: cell movement, extracellular matrix formation, tumor formation and cell adherence [ 1 ] . As described above, the membrane-bound precursor of HB-EGF (proHB-EGF) is also the cell-surface receptor for diphtheria toxin (DT) in DT-sensitive cells [ 2 ] .
In the present report, we have identified two novel extracellular matrix proteins latent transforming growth factor β-binding protein 3 and fibulin-1C that interact with the extracellular domain of proHB-EGF.
Previously we have examined the protein-protein interactions of proHB-EGF with the cell-surface CD9 antigen [ 9 ] . The CD9 antigen is found on a wide variety of tissue and cell types and has been reported to be involved in such cellular processes as B-cell development, cell metastasis, platelet activation and adhesion, and cell motility [ 14 15 ] . CD9 antigen is a member of the tetraspanin superfamily and consists of two extracellular domains sandwiched between four highly-conserved hydrophobic transmembrane domains [ 14 15 ] . The second extracellular domain (75-130 amino acids) is larger than the first extracellular domain (20-27 amino acids).
The interactions of LTBP-3 and fibulin-1C with the extracellular domain of proHB-EGF may provide further insights into the roles that these proteins play in cellular and tissue development processes.
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