Words similar to progenitor
Example sentences for: progenitor
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Isolated human neural progenitors spontaneously aggregate in these conditions to produce a cell cluster called a NS, and 85%–90% of NS cells produce the intermediary filament Nestin (Figures 1 and 2), a putative marker of neural stem and progenitor cells [19].
This can be understood by considering the facts that the human population is highly outbred, and L1 elements are preferentially cis -acting [ 24 27 ] . Progenitor elements for L1-TDs must be transpositionally competent and thus are likely to be relatively young.
Entire lobules and large ducts of normal breast tissue can be derived from a single progenitor cell [ 47 ] , and LOH at various chromosomal locations is frequently detectable in morphologically normal lobules adjacent to breast tumors [ 48 ] . Lung tumors and head and neck tumors that develop in a localized region also often have a common clonal origin [ 3 4 49 ] . The high frequency of M6P/IGF2R loss of heterozygosity observed in the head and neck tumors in this study suggests that the phenomenon of "field cancerization", first described by Slaughter and his colleagues [ 2 ] in 1953, may in part result from the clonal proliferation of mucosal epithelial cells with M6P/IGF2R allelic loss.
The resolution of this issue is further clouded by the apparent contradictory findings that IFN-γ is an extremely potent anti-osteoclastogenic factor [ 38 ] but it can be found at high levels in sites of osteolysis [ 39 ] . To reconcile this controversy we performed a series of experiments aimed at understanding how IFN-γ could induce either bactericidal effects via macrophage activation or osteoclastic bone resorption, by influencing the same progenitor cell in the same bone environment.
These results suggest that the combination of ectopic Msx1 expression and serum stimulation can induce differentiated muscle cells to dedifferentiate into proliferating multipotent progenitor cells.
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