Words similar to profound

Example sentences for: profound

How can you use “profound” in a sentence? Here are some example sentences to help you improve your vocabulary:

The effect of SAHA was profound on the nuclear PCNA fraction in both cell lines, but minimal on the cytoplasmic PCNA fraction.
This is an important new area of research that could conceivably lead to more physiological sleep aids than are currently available, with profound implications for improved public health.
Though he hasn't screwed up in any profound way, Apple contended, Clinton will be remembered as a middling president, at best.
Thus the advent of the CD8 +CD28 -cell in aging, with its potential for proinflammatory cytokines, could have profound effects not only on autoimmune diseases, but on Alzheimer's disease as well since cytokines may contribute to the neuropathology [ 72 ] .
Chambers, in other words, is one of the most controversial Americans of the last half-century, his life a story rife with histrionic tableaux, profound ideological warfare, and high-level scandal.