Words similar to prodrugs
Example sentences for: prodrugs
How can you use “prodrugs” in a sentence? Here are some example sentences to help you improve your vocabulary:
[ 25 26 ] Oral fluoropyrimidines and oral regimens using prodrugs of 5-FU or inhibitors of dihydropyrimidine dehydrogenase (DPD) which pharmacologically simulate the intravenous continuous infusion administration of 5-FU are currently under clinical evaluation.
However, some of the prodrugs are very effective against tumors in mouse models.
Despite ongoing, albeit reduced, viral replication in the animals, selection of resistant HSV with the prodrugs proved difficult.
Because of the high catalytic efficiency and broad substrate specificity, β-lactamases have been extensively used in the ADEPT approach to activate prodrugs of vinca alkaloids [ 27 ] , nitrogen mustard [ 28 29 30 31 32 ] , doxorubicin [ 33 34 35 36 ] and others [ 37 ] . To take advantage of the potent antitumor activity of the CC-1065 class of compounds and the ADEPT approach, we have synthesized β-lactam prodrugs.
Due to the slow non-enzymatic degradation of the cephalosporins in solution [ 39 ] , the ratio of toxicity of cephalosporin-containing prodrugs to their corresponding free drugs is generally not very high.