Words similar to prodrug

Example sentences for: prodrug

How can you use “prodrug” in a sentence? Here are some example sentences to help you improve your vocabulary:

For example, a cephalosporin-doxorubicin prodrug was 9-fold less toxic than free doxrubicin against tumor cells in vitro, but caused tumor regression when tested in tumor xenograft models [ 40 ] . A cephalosporin-vinca alkaloid prodrug was 5-fold less toxic than the free drug against tumor cells in vitro, but was highly effective in tumor xenograft models in vivo [ 41 ] . When taxol was conjugated to a cephalosporin, the resulting prodrug was approximately 10-fold less toxic than free taxol against tumor cells in vitro [ 36 ] . Thus, prodrug 2 has the potential to be useful in cancer treatment using the ADEPT approach.
Prodrug 2 was synthesized as shown in Figure 3. The key intermediate, 7 , was made using methods developed by Jungheim et al.
Compound 1 was treated with 7 in DMF to afford the protected prodrug 8 . Removal of the t-butyl protection group from 8 generated the targeted prodrug 2 with good yield.
The preliminary in vitro studies show the prodrug to be less toxic than the free drug.
This selective activation of prodrug 2 at the tumor site will lead to enhanced antitumor therapeutic efficacy.