Words similar to prodrug
Example sentences for: prodrug
How can you use “prodrug” in a sentence? Here are some example sentences to help you improve your vocabulary:
The solid was filtered, and washed with ether to afford prodrug 2 (3.
Prodrug 2 is expected to be less toxic than its corresponding free drug 1 . However, it is expected that the prodrug will be converted to the potent free drug by β-lactamases localized on the tumor cell surface by an antibody (Figure 2).
The cytotoxicity of prodrug 2 and its corresponding free drug 1 was tested against U937 leukemia cells, and the results are presented in Table 1. When the drugs were incubated with U937 cells for a period of 48-h, prodrug 2 (IC 50 : 0.9 nM) is 10-fold less toxic than its corresponding free drug 1 (IC 50 : 0.09 nM).
This selective activation of prodrug 2 at the tumor site will lead to enhanced antitumor therapeutic efficacy.
Sub-optimal therapy of immunocompetent mice with either VCV or FCV did not readily select for HSV-mutants resistant to either ACV or PCV, suggesting that selection of resistance with either prodrug remains difficult using this system.