Example sentences for: prodrug

How can you use “prodrug” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The solid was filtered, and washed with ether to afford prodrug 2 (3.

  • Prodrug 2 is expected to be less toxic than its corresponding free drug 1 . However, it is expected that the prodrug will be converted to the potent free drug by β-lactamases localized on the tumor cell surface by an antibody (Figure 2).

  • The cytotoxicity of prodrug 2 and its corresponding free drug 1 was tested against U937 leukemia cells, and the results are presented in Table 1. When the drugs were incubated with U937 cells for a period of 48-h, prodrug 2 (IC 50 : 0.9 nM) is 10-fold less toxic than its corresponding free drug 1 (IC 50 : 0.09 nM).

  • This selective activation of prodrug 2 at the tumor site will lead to enhanced antitumor therapeutic efficacy.

  • Sub-optimal therapy of immunocompetent mice with either VCV or FCV did not readily select for HSV-mutants resistant to either ACV or PCV, suggesting that selection of resistance with either prodrug remains difficult using this system.


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