Words similar to prodrug

Example sentences for: prodrug

How can you use “prodrug” in a sentence? Here are some example sentences to help you improve your vocabulary:

To evaluate efficacy of prodrug treatment in this model, VCV and FCV were provided in the drinking water at 1.0 mg/ml or at 0.2 mg/ml (sub-optimal treatment) for mice infected with either HSV-1 SC16 or HSV-2 SB5.
Compound 1 was treated with 7 in DMF to afford the protected prodrug 8 . Removal of the t-butyl protection group from 8 generated the targeted prodrug 2 with good yield.
The cytotoxicity of prodrug 2 and its corresponding free drug 1 was tested against U937 leukemia cells, and the results are presented in Table 1. When the drugs were incubated with U937 cells for a period of 48-h, prodrug 2 (IC 50 : 0.9 nM) is 10-fold less toxic than its corresponding free drug 1 (IC 50 : 0.09 nM).
Prodrug 2 is expected to be less toxic than its corresponding free drug 1 . However, it is expected that the prodrug will be converted to the potent free drug by β-lactamases localized on the tumor cell surface by an antibody (Figure 2).
Antibody-directed enzyme prodrug therapy (ADEPT) [ 1 2 3 4 5 ] is one of the promising new approaches that selectively target tumor cells, thus reducing toxic side effects to patients.