Example sentences for: prodrug

How can you use “prodrug” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Antibody-directed enzyme prodrug therapy (ADEPT) [ 1 2 3 4 5 ] is one of the promising new approaches that selectively target tumor cells, thus reducing toxic side effects to patients.

  • Prodrug 2 is expected to be less toxic than its corresponding free drug 1 . However, it is expected that the prodrug will be converted to the potent free drug by β-lactamases localized on the tumor cell surface by an antibody (Figure 2).

  • The cytotoxicity of prodrug 2 and its corresponding free drug 1 was tested against U937 leukemia cells, and the results are presented in Table 1. When the drugs were incubated with U937 cells for a period of 48-h, prodrug 2 (IC 50 : 0.9 nM) is 10-fold less toxic than its corresponding free drug 1 (IC 50 : 0.09 nM).

  • This selective activation of prodrug 2 at the tumor site will lead to enhanced antitumor therapeutic efficacy.

  • Acyclovir has been in part superceded by the oral prodrugs valaciclovir (VCV) and famciclovir (FCV), the latter being the oral version of PCV [ 20 24 ] . No comparative studies of the emergence of resistance following sub-optimal VCV or FCV have been reported and therefore set out to to select for HSV-1 and HSV-2 isolates resistant to ACV and PCV after using prodrug selection.


How many words do you know? Try our free vocabulary size test!


Search

Search for example sentences

Loading Loading...
Quantcast