Words similar to prodrug

Example sentences for: prodrug

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Prodrug 2 is expected to be less toxic than its corresponding free drug 1 . However, it is expected that the prodrug will be converted to the potent free drug by β-lactamases localized on the tumor cell surface by an antibody (Figure 2).
For example, a cephalosporin-doxorubicin prodrug was 9-fold less toxic than free doxrubicin against tumor cells in vitro, but caused tumor regression when tested in tumor xenograft models [ 40 ] . A cephalosporin-vinca alkaloid prodrug was 5-fold less toxic than the free drug against tumor cells in vitro, but was highly effective in tumor xenograft models in vivo [ 41 ] . When taxol was conjugated to a cephalosporin, the resulting prodrug was approximately 10-fold less toxic than free taxol against tumor cells in vitro [ 36 ] . Thus, prodrug 2 has the potential to be useful in cancer treatment using the ADEPT approach.
The HL60/TLK286 cell line is resistant to the prodrug TLK286 and derived from the wild-type HL60 by stepwise selection.
Sub-optimal therapy of immunocompetent mice with either VCV or FCV did not readily select for HSV-mutants resistant to either ACV or PCV, suggesting that selection of resistance with either prodrug remains difficult using this system.
This is the first report demonstrating synthesis of a prodrug comprised of a cephalosporin and a CC-1065 analogue.