Words similar to prodrug

Example sentences for: prodrug

How can you use “prodrug” in a sentence? Here are some example sentences to help you improve your vocabulary:

Subsequent administration of a prodrug substrate of the enzyme leads to the enzyme-catalyzed release of the free drug at the tumor site.
Prodrug 2 is expected to be less toxic than its corresponding free drug 1 . However, it is expected that the prodrug will be converted to the potent free drug by β-lactamases localized on the tumor cell surface by an antibody (Figure 2).
Acyclovir has been in part superceded by the oral prodrugs valaciclovir (VCV) and famciclovir (FCV), the latter being the oral version of PCV [ 20 24 ] . No comparative studies of the emergence of resistance following sub-optimal VCV or FCV have been reported and therefore set out to to select for HSV-1 and HSV-2 isolates resistant to ACV and PCV after using prodrug selection.
The cytotoxicity of prodrug 2 and its corresponding free drug 1 was tested against U937 leukemia cells, and the results are presented in Table 1. When the drugs were incubated with U937 cells for a period of 48-h, prodrug 2 (IC 50 : 0.9 nM) is 10-fold less toxic than its corresponding free drug 1 (IC 50 : 0.09 nM).
Sub-optimal therapy of immunocompetent mice with either VCV or FCV did not readily select for HSV-mutants resistant to either ACV or PCV, suggesting that selection of resistance with either prodrug remains difficult using this system.