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Example sentences for: probands

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Increased absolute frequencies of A*01-B*60, A*02-B*39, A*02-B*62, A*03-B*13, A*03-B*15, A*03-B*27, A*03-B*44, A*03-B*47, and A*03-B*57 were detected in the present cohort of Alabama hemochromatosis probands, but these haplotypes have not been reported to occur with increased absolute frequency in other hemochromatosis populations.
Homozygosity for these haplotypes was observed in some probands: A*01-B*08 (n = 1); A*02-B*07 (n = 1); A*02-B*44 (n = 1); and A*03-B*07 (n = 12).
After performing the Bonferroni corrections, the frequency of A*02-B*44 alone was significantly increased in probands ( p < 0.0085) (Table 4).
Some probands were homozygous for B alleles by DNA-based typing and family studies: B*07 (n = 13), B*08 (n = 3), B*37 (n = 1), B*44 (n = 2), and B*51 (n = 1).
Population-based studies of SAH probands show that 7 to 10% have a family history of IA, a higher percentage than previously appreciated [ 1 19 20 ] . These familial IA (FIA) families have no signs of any other simple Mendelian disorders predisposing to IA, supporting the possibility that some or all IAs have a genetic component, and that FIA is a genetic disease separate and apart from previously defined diseases.