Words similar to pro-apoptotic
Example sentences for: pro-apoptotic
How can you use “pro-apoptotic” in a sentence? Here are some example sentences to help you improve your vocabulary:
RPA with the multiple-probe of rAPO-1 showed that relative mRNA levels of Bcl-x short isoform (Bcl-xS), known as pro-apoptotic factors, initially decreased at 1 day, 3 days and 1 week followed by returning to base line level after 2W (Figure 4).
The highly acidic carboxy-terminal (BRCT) region of BRCA1 has been suggested to play a role in transactivation [ 11 ] . BRCT interacts with BRCA2, Rad51, other tumor suppressing elements, as well as numerous transcription factors, such as RNA helicase A and STAT1 [ 15 16 ] . Recently, it has been discovered that truncation of this region resulted in suppression of apoptosis following pro-apoptotic stimuli [ 17 ] . Further, these studies also suggested that the BRCT region facilitates apoptotic functions within the caspase pathway.
Although this mutant translocates to mitochondria as efficiently as does the WT with diminished disruptive effect on the outer membrane, it seems conceivable that tBid harbors two distinct signals, one for translocation to mitochondria, and the other for interaction with proteins or lipids to exert its pro-apoptotic function.
We previously reported that enhanced liver apoptosis in response to the antihepatocarcinogen rotenone was preceded and accompanied by a marked increase in the hepatic levels of c-myc mRNA [ 10 ] , a proto-oncogene that plays a dual role in cell proliferation and apoptosis [ 24 ] . Since in our study [ 10 ] rotenone inhibited hepatocellular proliferation while enhancing apoptosis, we concluded that the increase in c-myc mRNA expression acted as a pro-apoptotic signal in the liver.
The apoptosis regulators included several anti-apoptotic genes discussed previously ( A20, MCL1, c-IAP2 ), as well as potentially pro-apoptotic genes such as those for Fas ligand and TNF receptor type II.
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