Words similar to pro-apoptotic
Example sentences for: pro-apoptotic
How can you use “pro-apoptotic” in a sentence? Here are some example sentences to help you improve your vocabulary:
We previously reported that enhanced liver apoptosis in response to the antihepatocarcinogen rotenone was preceded and accompanied by a marked increase in the hepatic levels of c-myc mRNA [ 10 ] , a proto-oncogene that plays a dual role in cell proliferation and apoptosis [ 24 ] . Since in our study [ 10 ] rotenone inhibited hepatocellular proliferation while enhancing apoptosis, we concluded that the increase in c-myc mRNA expression acted as a pro-apoptotic signal in the liver.
Although this mutant translocates to mitochondria as efficiently as does the WT with diminished disruptive effect on the outer membrane, it seems conceivable that tBid harbors two distinct signals, one for translocation to mitochondria, and the other for interaction with proteins or lipids to exert its pro-apoptotic function.
A significant portion of the outer membrane was absent in most mitochondria observed, which may have been caused in part by the activity of this pro-apoptotic protein in releasing cytochrome c from the region between the outer and inner membranes.
Truncated Bid, as other BH3-only proteins, requires another protein such as Bax or Bak to exert its pro-apoptotic function [ 23 24 ] . Interestingly, tBid was found associated with mitochondrial contact sites (Figs.
Comparative genomic analyses of orthologous drosophilid genes should aid in this endeavor, as evidenced by the recent demonstration that several conserved motifs in the 3' UTR of the pro-apoptotic gene hid are targets of the miRNA bantam [ 44 ] . Statistically significant pairings of conserved and/or overrepresented 3' UTR motifs can be assessed for complementarity to miRNAs.
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