Words similar to pro-apoptotic
Example sentences for: pro-apoptotic
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Naturally occurring triterpenoids, such as ursolic acid, have been found to have mild anti-inflammatory effects [ 18 27 ] . These have been improved with the development of synthetic triterpenoids such as CDDO, offering a potential therapeutic tool for the treatment of arthritis and other diseases [ 19 20 21 ] . Furthermore, it has been reported that CDDO at high doses (5-10 μM) can have pro-apoptotic effects, ideal for the treatment of leukemia but of concern with regard to chondrocyte cell death [ 25 26 ] . However, we found that CDDO, at concentrations that decrease MMP-1 and MMP-13 expression (namely 300 nM and 1 μM), did not cause cell death.
FACS analysis demonstrated that these cells were all apoptotic (not shown, see also [ 36 ] ). Although TGFβ1 acted anti-apoptotically in PP cultures (palmar and normal plantar fibroblasts) and prevented the shedding of cells into the media, its effect was dissimilar in non-PP cultures, where TGFβ1 had either no impact (keloid T and normal nonplantar fibroblasts) or was pro-apoptotic (keloid D cultures).
HSP70 and GRP78 both have anti-apoptotic activity, whereas HSP90 appears to have both pro-apoptotic and anti-apoptotic activities, depending on the specific stimuli received.
RPA with the multiple-probe of rAPO-1 showed that relative mRNA levels of Bcl-x short isoform (Bcl-xS), known as pro-apoptotic factors, initially decreased at 1 day, 3 days and 1 week followed by returning to base line level after 2W (Figure 4).
Truncated Bid, as other BH3-only proteins, requires another protein such as Bax or Bak to exert its pro-apoptotic function [ 23 24 ] . Interestingly, tBid was found associated with mitochondrial contact sites (Figs.
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