Words similar to pro-apoptotic
Example sentences for: pro-apoptotic
How can you use “pro-apoptotic” in a sentence? Here are some example sentences to help you improve your vocabulary:
As the sense transcript codes for a pro-apoptotic gene, the result immediately suggests the interesting hypothesis that upregulation of the antisense RNA species in cancer tissues has functional relevance with respect to suppression of the potentially tumor-suppressing sense gene.
It had a pro-apoptotic effect on myofibroblasts.
FACS analysis demonstrated that these cells were all apoptotic (not shown, see also [ 36 ] ). Although TGFβ1 acted anti-apoptotically in PP cultures (palmar and normal plantar fibroblasts) and prevented the shedding of cells into the media, its effect was dissimilar in non-PP cultures, where TGFβ1 had either no impact (keloid T and normal nonplantar fibroblasts) or was pro-apoptotic (keloid D cultures).
Naturally occurring triterpenoids, such as ursolic acid, have been found to have mild anti-inflammatory effects [ 18 27 ] . These have been improved with the development of synthetic triterpenoids such as CDDO, offering a potential therapeutic tool for the treatment of arthritis and other diseases [ 19 20 21 ] . Furthermore, it has been reported that CDDO at high doses (5-10 μM) can have pro-apoptotic effects, ideal for the treatment of leukemia but of concern with regard to chondrocyte cell death [ 25 26 ] . However, we found that CDDO, at concentrations that decrease MMP-1 and MMP-13 expression (namely 300 nM and 1 μM), did not cause cell death.
The apoptosis regulators included several anti-apoptotic genes discussed previously ( A20, MCL1, c-IAP2 ), as well as potentially pro-apoptotic genes such as those for Fas ligand and TNF receptor type II.
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