Words similar to pro-apoptotic
Example sentences for: pro-apoptotic
How can you use “pro-apoptotic” in a sentence? Here are some example sentences to help you improve your vocabulary:
As the sense transcript codes for a pro-apoptotic gene, the result immediately suggests the interesting hypothesis that upregulation of the antisense RNA species in cancer tissues has functional relevance with respect to suppression of the potentially tumor-suppressing sense gene.
Truncated Bid, as other BH3-only proteins, requires another protein such as Bax or Bak to exert its pro-apoptotic function [ 23 24 ] . Interestingly, tBid was found associated with mitochondrial contact sites (Figs.
Human Fhit protein, a member of the Fhit branch of the histidine triad superfamily of nucleotide-binding proteins, binds and hydrolyzes diadenosine polyphosphates such as ApppA and AppppA ( 1 ) into AMP plus ADP and ATP, respectively [ 8 9 10 ] . His96, which is responsible for covalent catalysis and more than 4× 10 6-fold of rate enhancement in ApppA hydrolysis [ 9 11 12 13 ] , is nonetheless dispensable for ApppA-binding and tumor suppression, suggesting that Fhit function in tumor suppression depends on formation of an E-S complex [ 2 12 ] . If Fhit-substrate complexes promote tumor suppression by stimulating a pro-apoptotic effector, then Fhit inhibitors that resemble natural substrates may promote Fhit function.
FACS analysis demonstrated that these cells were all apoptotic (not shown, see also [ 36 ] ). Although TGFβ1 acted anti-apoptotically in PP cultures (palmar and normal plantar fibroblasts) and prevented the shedding of cells into the media, its effect was dissimilar in non-PP cultures, where TGFβ1 had either no impact (keloid T and normal nonplantar fibroblasts) or was pro-apoptotic (keloid D cultures).
In contrast to the pro-apoptotic role for Btk in DT40 cells, Btk appears to play an anti-apoptotic role in mature B cells in vivo . The mechanism may involve Btk-dependent activation of the transcription factor NF-κ B [ 7, 10] and subsequent upregulation of the anti-apoptotic protein Bcl-X L [ 39, 40].
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