Words similar to preclinical
Example sentences for: preclinical
How can you use “preclinical” in a sentence? Here are some example sentences to help you improve your vocabulary:
Some heteroclitic tumor antigen peptides that showed highly improved antigenicity and immunogenicity in preclinical studies, and which also cross-reacted well with CTLs generated against the parental sequence, were tested in clinical trials.
However, the present data in a well-established preclinical model of breast cancer, employing a variety of highly effective chemopreventive regimens, suggest that this is not the case.
Amprenavir (APV) is a potent protease inhibitor (PI) that is used in combination with other antiretroviral drugs for the treatment of antiretroviral-naïve and -experienced adults and children with HIV infection [ 1 2 3 4 5 ] . APV offers the convenience of twice-daily (BID) administration with no food or fluid restrictions [ 6 7 ] . Preclinical and clinical data suggest that APV has a lower potential to cause lipodystrophy and metabolic abnormalities than other currently available PIs [ 8 9 10 ] . APV has a distinct resistance profile that permits it to be considered as a treatment option for either PI-naïve or PI-experienced patients [ 11 ] . In a 64-week trial in treatment-naïve patients (NZTA4002; n = 302), APV 1200 mg, administered BID (APV1200) with one abacavir 300 mg tablet and one lamivudine 150 mg/zidovudine 300 mg combination tablet (Combivir ®), was as effective as nelfinavir 750 mg three times daily plus Combivir BID, with regard to the proportion of patients achieving HIV-1 RNA <40 copies/mL at week 64: 77% vs 66% (as-treated analysis) [ 12 ] . However, many patients in this trial withdrew prematurely because of adverse events that may have been, in part, related to the high pill burden (16 large 150 mg soft-gelatin capsules daily) associated with APV dosing and excipients contained in the APV formulation available at the time of the trial.
Because chemopreventive agents are unlikely to be given to humans during the pubertal period, this form of preclinical model may not accurately reflect the degree of chemopreventive benefit that could be achieved in humans.
Research on HIV vaccines and prevention relies strongly on preclinical studies in macaque models for the identification and evaluation of potential vaccines or prophylactic treatment strategies [3].
Loading...