Words similar to pre-mi
Example sentences for: pre-mi
How can you use “pre-mi” in a sentence? Here are some example sentences to help you improve your vocabulary:
This suggested that miRNA genes might be found by folding fixed lengths of conserved sequence to identify ones that display the high degree of relatively continuous helicity characteristic of known pre-miRNAs.
Thus, the terminal loop is the most evolutionary labile portion of pre-miRNA.
Processing of pri-miRNA into the pre-miRNA stem-loop occurs in the nucleus, while subsequent processing of pre-miRNA into 21-22 mers is a cytoplasmic event mediated by the RNAse III enzyme Dicer [ 17 18 19 20 ] ; Dicer is also responsible for cleavage of long perfectly double-stranded RNA into 21-22 nucleotide fragments during RNA interference (RNAi) [ 2 21 ] . These latter molecules, known as silencing RNA (siRNA), bind to and trigger the degradation of perfectly homologous mRNA molecules via RISC, a double-strand RNA-induced silencing complex containing nuclease activity [ 22 23 ] .
Although most known pre-miRNAs in Drosophila , Caenorhabditis , mice and humans form relatively canonical stem-loops of around 70 to 100 nucleotides in length, plant miRNA precursors are often processed through exceptionally long stem-loops (many 150 nucleotides or longer) [ 14 15 16 ] . miR-125 is a member of the Drosophila reference set that received a low score by our informatic procedure, possibly because it may derive from an unusually long stem-loop (120 nucleotides), only a portion of which was included in the queried window.
There are only three pairs that have been completely conserved (Figure 2a, class 1), indicating that most pre-miRNAs have diverged to some extent within Drosophila . Unexpectedly, we detected mild selective pressure on the precise sequence of the non-miRNA-encoding arm.
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