Words similar to pre-mi
Example sentences for: pre-mi
How can you use “pre-mi” in a sentence? Here are some example sentences to help you improve your vocabulary:
First, the mature miRNA can be derived from either arm of a given stem-loop, and many predicted pre-miRNAs fold well on either strand.
There are only three pairs that have been completely conserved (Figure 2a, class 1), indicating that most pre-miRNAs have diverged to some extent within Drosophila . Unexpectedly, we detected mild selective pressure on the precise sequence of the non-miRNA-encoding arm.
First, the loop appears to be the least critical feature of a pre-miRNA, an observation supported by the identification of orthologous insect miRNAs that vary quite significantly in terms of both loop size and sequence (data not shown).
The starting point for our studies was a reference set of 24 Drosophila pre-miRNA sequences ( let-7 , the 21 originally identified by Lagos-Quintana and colleagues, mir-125 , and a previously undescribed paralog of mir-2 that we named mir-2c [ 9 10 29 ] ). We analyzed this set to derive rules and determine parameters that specifically describe known miRNA genes within anonymous genomic sequence.
Although most known pre-miRNAs in Drosophila , Caenorhabditis , mice and humans form relatively canonical stem-loops of around 70 to 100 nucleotides in length, plant miRNA precursors are often processed through exceptionally long stem-loops (many 150 nucleotides or longer) [ 14 15 16 ] . miR-125 is a member of the Drosophila reference set that received a low score by our informatic procedure, possibly because it may derive from an unusually long stem-loop (120 nucleotides), only a portion of which was included in the queried window.
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