Words similar to prazosin
Example sentences for: prazosin
How can you use “prazosin” in a sentence? Here are some example sentences to help you improve your vocabulary:
The VA Cooperative Study on Antihypertensive agents was a double-blind, randomized controlled trial comparing atenolol, captopril, clonidine, diltiazem, hydrochlorothiazide, prazosin, and placebo for differences in antihypertensive efficacy in 1,105 men who had mild diastolic hypertension [ 10 ] . A highly significant weight gain of 1 kilogram was observed at 8 weeks with prazosin compared to baseline (p < .001), and this gain was also statistically significant when compared to the 8-week weight changes in all other groups that had experienced either weight loss or no mean weight change (p < 0.05).
He noted that prazosin blocks heat shock protein expression in myocardium, and it has been hypothesized that this may leave myocardium more vulnerable to injury [ 20 ] .
1%) [ 11 ] . The number of men treated with prazosin decreased from 62 at the beginning of the trial to 28 by the end.
There was no weight change in that study, but two other studies demonstrated both an increase in weight as well as laboratory changes consistent with volume expansion for prazosin [ 8 9 ] . Bauer and his colleagues suggested that a net increase in total body sodium from an acute renal effect of prazosin was offset by a decrease in actual body weight.
A 1984 study of prazosin reported by Bauer revealed increases in plasma volume, interstitial fluid volume, and extracellular fluid volume following both short-term and long-term therapy [ 7 ] . In this study of 14 hypertensive men, there was a significant 1.4 L average increase in ECFV, with a 200 mL average increase in plasma volume (measured with radioisotopic assays) that occurred within 3-6 weeks of initiation, lasted during 5 to 6 months of chronic therapy, and was still present during a two-week washout period.
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