Words similar to pparα
Example sentences for: pparα
How can you use “pparα” in a sentence? Here are some example sentences to help you improve your vocabulary:
Thus, LC-PUFA can activate PPARα/RXRα, leading to displacement of HNF4α from PPRE; or be converted to CoA derivatives, which in turn can suppress HNF4α transcriptional activity.
These same conclusions regarding energy expenditure were reached in experiments assessing enzymatic activities, and transcriptional changes in rat liver using Northern blots, where fish oil feeding: increased palmitoyl CoA mitochondrial and peroxisomal oxidation rate; increased Cpt1, Cpt2, Δ 3, Δ 2-enoyl CoA isomerase, and Ech1 expression and activity; and decreased expression and activity of FA synthase, malic enzyme, glucose 6-phosphate dehydrogenase, and pyruvate kinase, compared to palm and/or safflower oil feeding [ 93 ] . Likewise, in rat white retroperitoneal adipose tissue, fish oil feeding also decreased Fasn expression [ 94 ] . Intriguingly, the hormone leptin, which also acts through SREBP-1 and PPARα, affected many transcripts similarly to LC-PUFA ( e.g. , leptin decreased Gpam and Apoa4 transcripts; and up regulated Ech1, mitochondrial Hmgcs2, and Cyp4a14 transcripts [ 95 ] .
Peroxisome proliferator-activated receptors (PPARs) belong to a group of nuclear receptors which includes steroid, retinoid, thyroid hormone receptors and others [ 19 20 21 ] . There are three types of PPARs: PPARα is found predominantly in the liver, heart, kidney, brown adipose and stomach mucosa, and is important for lipid catabolism.
Peroxisome proliferator-activated receptors (PPARs) belong to a group of nuclear receptors that include steroid, retinoid, thyroid hormone receptors and others [ 21 22 23 ] . There are three types of PPARs: PPARα is expressed predominantly in the liver, heart, kidney, brown adipose and stomach mucosa, and is important for lipid catabolism.
On the other hand, many synthetic compounds such as the non-steroid anti-inflammatory drugs (NSAIDs) are PPARα and PPARγ agonists [ 27 ] . Since these are agents used clinically for other purposes, it is important to determine whether interaction of these agents with PPARs could modulate atherogenesis in a positive or negative manner.
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