Words similar to pparα
Example sentences for: pparα
How can you use “pparα” in a sentence? Here are some example sentences to help you improve your vocabulary:
Chronic feeding of fish and AA-enriched fungal oils broadly affected genes regulated by PPARα, HNFα, and SREBP-1 in the liver; transcription factors implicated in lipid metabolism as well as other processes.
Rat G6pc has HNF4α consensus binding sites [ 52 ] . In HeLa cells and HepG2 hepatoma cells, PUFA down regulated G6pc, possibly via inhibition of HNF 4α promoter activity [ 52 ] . In our current mouse experiment, the transcriptional effects of LC-PUFA on G6pc may thus have been HNF4α- or PPARα mediated.
These same conclusions regarding energy expenditure were reached in experiments assessing enzymatic activities, and transcriptional changes in rat liver using Northern blots, where fish oil feeding: increased palmitoyl CoA mitochondrial and peroxisomal oxidation rate; increased Cpt1, Cpt2, Δ 3, Δ 2-enoyl CoA isomerase, and Ech1 expression and activity; and decreased expression and activity of FA synthase, malic enzyme, glucose 6-phosphate dehydrogenase, and pyruvate kinase, compared to palm and/or safflower oil feeding [ 93 ] . Likewise, in rat white retroperitoneal adipose tissue, fish oil feeding also decreased Fasn expression [ 94 ] . Intriguingly, the hormone leptin, which also acts through SREBP-1 and PPARα, affected many transcripts similarly to LC-PUFA ( e.g. , leptin decreased Gpam and Apoa4 transcripts; and up regulated Ech1, mitochondrial Hmgcs2, and Cyp4a14 transcripts [ 95 ] .
Mitochondrial Hmgcs2 is known to be induced by PPARα activation in experiments with hepatocytes [ 72 73 ] . The cytosolic form involved in cholesterol biosynthesis was not affected.
While 15d-PGJ 2 is considered to be a PPARγ agonist, indomethacin and ibuprofen can activate both PPARγ and PPARα [ 27 ] . The following experiment was conducted to determine if a pure PPARα agonist, WY14643, could modulate the 25-OH-cholesterol induced cytotoxicity.
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