Words similar to pparα

Example sentences for: pparα

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Chronic feeding of fish and AA-enriched fungal oils broadly affected genes regulated by PPARα, HNFα, and SREBP-1 in the liver; transcription factors implicated in lipid metabolism as well as other processes.
The levels of either PPARα mRNA or PPARβ mRNA are not altered under the same conditions.
Peroxisome proliferator-activated receptors (PPARs) belong to a group of nuclear receptors that include steroid, retinoid, thyroid hormone receptors and others [ 21 22 23 ] . There are three types of PPARs: PPARα is expressed predominantly in the liver, heart, kidney, brown adipose and stomach mucosa, and is important for lipid catabolism.
PPREs are direct repeats (DR) of a hexanucleotide sequence AGGTCA separated by one nucleotide and are therefore referred to as a DR-1 response element [ 30 ] . PPARα and PPARγ play critical roles in the catabolism and storage of FA, whereas the function of PPARδ is less certain.
Rat G6pc has HNF4α consensus binding sites [ 52 ] . In HeLa cells and HepG2 hepatoma cells, PUFA down regulated G6pc, possibly via inhibition of HNF 4α promoter activity [ 52 ] . In our current mouse experiment, the transcriptional effects of LC-PUFA on G6pc may thus have been HNF4α- or PPARα mediated.