Words similar to pparα

Example sentences for: pparα

How can you use “pparα” in a sentence? Here are some example sentences to help you improve your vocabulary:

The levels of either PPARα mRNA or PPARβ mRNA are not altered under the same conditions.
The PPARα agonist WY14643 had some saving effect at a high concentration (40 μM), however, the difference was not statistically significant (results not shown).
Peroxisome proliferator-activated receptors (PPARs) belong to a group of nuclear receptors which includes steroid, retinoid, thyroid hormone receptors and others [ 19 20 21 ] . There are three types of PPARs: PPARα is found predominantly in the liver, heart, kidney, brown adipose and stomach mucosa, and is important for lipid catabolism.
Rat G6pc has HNF4α consensus binding sites [ 52 ] . In HeLa cells and HepG2 hepatoma cells, PUFA down regulated G6pc, possibly via inhibition of HNF 4α promoter activity [ 52 ] . In our current mouse experiment, the transcriptional effects of LC-PUFA on G6pc may thus have been HNF4α- or PPARα mediated.
Thus, LC-PUFA can activate PPARα/RXRα, leading to displacement of HNF4α from PPRE; or be converted to CoA derivatives, which in turn can suppress HNF4α transcriptional activity.