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Example sentences for: ppars

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On the other hand, many synthetic compounds such as the non-steroid anti-inflammatory drugs (NSAIDs) are PPARα and PPARγ agonists [ 27 ] . Since these are agents used clinically for other purposes, it is important to determine whether interaction of these agents with PPARs could modulate atherogenesis in a positive or negative manner.
Other notable findings point to additional signaling proteins (CAMK, p38MAPK, and AMPK) and transcription factors (PGC-1, MEF2, ATF2, PPARs) active in pathways that intersect with calcineurin–NFAT signaling [31,43,44,45,46,47,48] (see Figure 2).
Transcription factors such as PPARs and SREBPs are also known to have an effect on various lipid transport genes.
Peroxisome proliferator-activated receptors (PPARs) belong to a group of nuclear receptors that include steroid, retinoid, thyroid hormone receptors and others [ 21 22 23 ] . There are three types of PPARs: PPARα is expressed predominantly in the liver, heart, kidney, brown adipose and stomach mucosa, and is important for lipid catabolism.
E-FABP is found in liver and other organs [ 68 ] , but it has been most studied in psoriatic skin lesions [ 69 ] where it has putative roles in FA cytoplasmic transport, skin barrier function and keratinocyte differentiation [ 70 ] . Although links between PPARs and E-FABP have not currently been identified, this gene clustered with other known PPAR-affected genes suggesting a possibly important regulatory link.