Words similar to ppars

Example sentences for: ppars

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E-FABP is found in liver and other organs [ 68 ] , but it has been most studied in psoriatic skin lesions [ 69 ] where it has putative roles in FA cytoplasmic transport, skin barrier function and keratinocyte differentiation [ 70 ] . Although links between PPARs and E-FABP have not currently been identified, this gene clustered with other known PPAR-affected genes suggesting a possibly important regulatory link.
In the present work, the focus will be on transcription factors previously identified as mediators of LC-PUFA actions, such as PPARs, SREBP, and HNFs.
Peroxisome proliferator-activated receptors (PPARs) belong to a group of nuclear receptors which includes steroid, retinoid, thyroid hormone receptors and others [ 19 20 21 ] . There are three types of PPARs: PPARα is found predominantly in the liver, heart, kidney, brown adipose and stomach mucosa, and is important for lipid catabolism.
Therefore DHA (22:6:n3) may require retroconversion via β-oxidation to an 18 C or 20 C LC-PUFA prior to activating PPARs [ 17 33 ] . Without the use of purified FA it is difficult to distinguish whether the DHA in our fish oil preparation was retroconverted since the fish oil also provided the retroconversion products, 20:5n3 and 22:5n3 (Table 3).
HNFs may compete with PPARs for binding to DR-1 elements.