Example sentences for: potentiate

How can you use “potentiate” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • These cofactors interact with nuclear receptors in a ligand-dependent manner and enhance transcriptional activation via histone acetylation/methylation and recruitment of additional cofactors such as CBP/p300 [ 89 ] . CBP/p300 has been implicated in the functions of a large number of regulated transcription factors based primarily on physical interaction and the ability to potentiate transcription when overexpressed [ 90 ] . In the case of nuclear receptors, the interaction with CBP/p300 is ligand-dependent and relies on the conserved nuclear receptor functional domain, AF-2 (activation function 2).

  • We sought to see if Gleevec can potentiate the cell killing effects of cisplatin, the leading chemotherapeutic drug for almost all advanced cancer patients.

  • This would disrupt the negative control of the receptor and potentiate the Ca 2+response.

  • For example, in insulin-secreting cell lines, PKC was reported to potentiate K ATP activity [ 11 12 ] , although PKC-dependent inhibition [ 13 ] or inhibition followed by activation [ 14 ] has been also reported.

  • The rationale, at least in part, for this phase II study comes from pre-clinical data suggesting MTX and LV potentiate the anti-tumor activity of 5-FU.


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