Words similar to potentiate
Example sentences for: potentiate
How can you use “potentiate” in a sentence? Here are some example sentences to help you improve your vocabulary:
For example, in insulin-secreting cell lines, PKC was reported to potentiate K ATP activity [ 11 12 ] , although PKC-dependent inhibition [ 13 ] or inhibition followed by activation [ 14 ] has been also reported.
Maintenance of splanchnic blood flow is important because splanchnic hypoperfusion may play a critical role in the pathogenesis of multiorgan dysfunction syndrome [ 2 3 ] . Mechanical ventilation has been suggested to potentiate the adverse effects of underlying critical illness on splanchnic vasculature and contribute to the development of multiorgan dysfunction syndrome, particularly when 'injurious' ventilatory strategies that produce high end-inspiratory lung volumes are employed [ 3 ] . Experimental studies suggested that mechanical ventilation with considerably high levels of PEEP can lead to splanchnic hypoperfusion and marked reduction in hepatic blood flow [ 4 5 6 ] . Furthermore, PEEP may decrease splanchnic blood flow in patients with no underlying lung disease [ 7 8 ] . Most available evidence regarding the effects of PEEP from animal studies has been extrapolated to humans based on the assumption that the effects of mechanical ventilation on humans and animals are similar.
Caspase 6 is activated by active Caspase 3 and in turn cleaves lamin, resulting in nuclear membrane fragmentation [ 55 ] . FAF interacts with the cytoplasmic domain of the Fas receptor to potentiate Fas-mediated apoptosis [ 56 57 ] . Thus, the up-regulated cell cycle inhibitors and apoptotic proteins clearly favor cell cycle arrest and death.
Cisplatin causes two types of DNA damage, DNA adducts and inter-stranded cross-linking, resulting in activation of apoptosis pathway in the target tumor cells [ 13 14 ] . Our results suggest that inhibition of tyrosine kinase activity of the potential targets by Gleevec appear to potentiate the effect of cisplatin in DNA-damage induced apoptosis in A549 cells.
Current study results suggests that Gleevec can potentiate the cisplatin effect on A549 lung cancer cells, and these findings provide important in vitro data for further testing the possibility of using Gleevec as adjuvant therapy for clinical lung cancer patients.
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