Words similar to postmitotic
Example sentences for: postmitotic
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At this stage, primary neurons have differentiated and some secondary neurons are postmitotic and have differentiated while others remain in the cell cycle [ 42].
In this report, we describe the application of PEI in the transfection of postmitotic rat sympathetic neurons in serum-free, glia-free conditions, thereby showing the capability of PEI as a method for studying the effects of targeted genetic manipulation in a rigorously defined cell culture system.
This may reflect androgen activity in restoring the glandular structure by promoting postmitotic differentiation [ 48 49 ] . Consistent with this view, androgen administration to intact rats resulted in suppression of prostate epithelial cell proliferation and maintenance of morphological gland integrity [ 50 ] . Based on these findings, we propose that the effects of high doses of androgens on SKP2 and p27 in LNCaP cells described here reflect a differentiation and consolidation effect in vitro . If this is the case, LNCaP cells, despite being highly aneuploid derivatives of a metastatic lesion of an advanced cancer [ 39 ] , may have retained some aspects of the normal biphasic mechanism of androgen control observed in castrated rodents.
Transfection conditions were optimized using cultures of postmitotic sympathetic neurons that had been treated with a DNA synthesis inhibitor to remove nonneuronal cells.
Among the intrinsic factors underlying asymmetric division, the interactions of the Numb differentiation-associated protein with Notch proliferation-associated signaling is the model most widely studied, ranging from bacteria, yeast, and Drosophila to mammals [ 30 ] . When the neuronal progenitor cells undergo asymmetric division (20% in neuronal tissue cell culture) they produce neuronal daughter cells to which Numb protein segregates preferentially, and such daughter cells show an enhanced differentiation of neuronal processes [ 45 ] . Interestingly, Numb is firstly associated with one pole of the plasma membrane of a dividing cell, and subsequently with one of the two resulting nuclei [ 29 45 ] . Our study indicates that preservation of nuclear ERα in one of two postmitotic cells is associated with the ability of CT to replicate and diminution of ERα and appearance of nuclear ERβ dictates a generation of a daughter cell that is committed to differentiate (Fig.
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