Words similar to pore-forming
Example sentences for: pore-forming
How can you use “pore-forming” in a sentence? Here are some example sentences to help you improve your vocabulary:
Voltage-gated K +currents with distinct electrophysiological and pharmacological properties are present in granulosa cells (GC), and modulate resting membrane potential [ 4 12 13 16 17 ] . Furthermore, selective antagonism of GC K +channels with distinct molecular correlates, electrophysiological properties and expression patterns can influence differentially GC proliferation, steroidogenic capability, and apoptosis [ 17 18 ] . Our laboratory has previously identified two distinct delayed rectifier K +currents in pig GC: a slow current (I Ks ) associated with channels formed by co-assembly of KCNQ1 pore-forming and KCNE1 accessory proteins, and an ultra-rapid current (I Kur ) formed by co-assembly of KCNA pore-forming and KCNAB accessory proteins [ 4 ] . Moreover, we have shown that selective block of I Ks enhances basal progesterone synthesis, while complete block of both I Ks and I Kur accelerates apoptosis [ 18 ] .
Fortunately, the putative bacterial KirBac sequences reported here can be aligned unambiguously with the pore-forming P and M2 segments of both KscA and the eukaryotic Kir's.
Overall, these data are consistent with previous reports that endocrine cells express voltage-sensitive ion channels that can contribute to the regulation of not only resting membrane potential and cell volume, but also cell proliferation and steroidogenesis [ 12 13 16 18 21 28 29 30 31 32 33 34 35 36 37 ] . The K +currents blocked by 4-AP in pig GC are conducted by ion channels formed by heteromeric complexes of pore-forming subunits from the KCNA (also called Kv1 or Shaker) family of proteins and accessory subunits from the KCNAB (also called Kvβ) family of proteins [ 4 ] . Similar 4-AP-sensitive K +currents play a key role in transduction of mitogenic signals in a variety of cell types, and 4-AP treatment has been associated with not only growth arrest but also apoptosis [ 2 3 8 9 10 14 38 39 40 41 42 ] .
Similarly, the fact that NaChBac is about equidistant from consensus sequences of all four 6TM motifs of eukaryotic Ca 2+channels [ 15 ] is consistent with the hypothesis that Ca 2+channels initially evolved first in prokaryotes as homotetramers from 6TM Kv-like channels and then underwent two consecutive gene duplication events to evolve into the eukaryotic Ca 2+channels that have only one pore-forming subunit that contains four consecutive 6TM motifs.
In fact, if only the P-M2 transmembrane pore-forming region is considered, KirBac's are more similar to some other K +channel families than to the eukaryotic Kir's (see below).
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